临床神经病学杂志Issue(3)：218-220,3.
脑血管储备对重度大脑中动脉狭窄所致内分水岭梗死患者发展转归的影响
Effects of cerebrovascular reserve on progress and outcome in patients with internal border zone infarction induced by severe middle cerebral artery stenosis
翟志永 1孙宜南 1冯娟1
作者信息
- 1. 110004沈阳，中国医科大学附属盛京医院神经内科
- 折叠
摘要
Abstract
Objective To assess cerebrovascular reserve ( CVR) function in patients with internal border zone infarction(IBZI) induced by severe middle cerebral artery (MCA) stenosis, and investigate the impact on progression and outcome of the disease .Methods A total of 84 patients with unilateral severe MCA stenosis were selected . Hypercapnia was induced by holding breath .The change of blood flow velocity in MCA was measured by transcranial Doppler ( TCD ) to calculate CVR .According to CVR , patients were divided into impaired regional CVR group ( CVR <10%) and normal CVR group ( CVR ≥10%) .The NIHSS was used to evaluate neurological function in both groups within 14 d, and mRS was used to evaluate acute stage outcome of the patients at discharge .All the patients were followed-up for 6 months, the incidences of recurrence , complications and mortality in the two groups were analyzed .Results The incidence of progressive cerebral infarction in the impaired regional CVR group (67.39%) was significantly higher than that in the normal CVR group (42.11%) ( P<0.05).The impaired regional CVR group showed higher proportion of patients with poor clinical outcome at discharge ( mRS≥3 ) (63.04%)compared to the normal CVR group (36.84%) (P<0.05).In the followed-up 6 months, the incidences of recurrence and complications were 34.78% and 45.65% respectively in the impaired regional CVR group , they were significantly higher than that in normal CVR group (15.79%,23.68%)(P<0.05).The overall mortality rates did not differ significantly between the two groups ( P>0.05 ) .Conclusion Impaired regional CVR may be predictive of subsequent progressive cerebral infarction and poor clinical outcomes in patients with IBZI induced by severe MCA stenosis .关键词
内分水岭梗死/脑血管储备/进展/转归/大脑中动脉Key words
internal border zone infarction/cerebrovascular reserve/progress/outcome/middle cerebral artery分类
医药卫生引用本文复制引用
翟志永,孙宜南,冯娟..脑血管储备对重度大脑中动脉狭窄所致内分水岭梗死患者发展转归的影响[J].临床神经病学杂志,2015,(3):218-220,3.
