临床神经外科杂志Issue(1)：13-16,4.DOI:10.3969/j.issn.1672-7770.2015.01.004
大鼠蛛网膜下腔出血后白介素33的变化和可能的作用
Change of IL-33 and possible effects in brain following SAH in rats
摘要
Abstract
Objective To study the change of IL-33 in the brain cortex after subarachnoid hemorrhage(SAH) in rats, and discuss the possible roles of IL-33 after SAH.Methods Sprague-Dawley ( SD) rats were randomly divided into sham group and SAH groups at 2 h, 6 h, 12 h,24 h and on day 2 , day 3 .Prechiasmatic cistern model of SAH was chosen .The change of IL-33 was measured by western blot and immunohistochemistry .The mRNA levels of IL-33 and IL-1βwere also detected by real-time PCR.Results Our study found that SAH could improve the level of IL-33 .And a positive relationship between IL-33 and IL-1βcould be found .Conclusion SAH induced a time-dependent upregulation of IL-33 mRNA and protein expression in the cortex ,and IL-33 might play an important role in the inflammation after SAH .关键词
蛛网膜下腔出血/白介素33/炎症Key words
subarachnoid hemorrhage/interleukin-33/inflammation分类
医药卫生引用本文复制引用
黄立添,孙青,厉华,杨毅卿,杭春华..大鼠蛛网膜下腔出血后白介素33的变化和可能的作用[J].临床神经外科杂志,2015,(1):13-16,4.基金项目
国家自然科学基金资助项目 （）
