临床误诊误治Issue(6)：41-44,4.DOI:10.3969/j.issn.1002-3429.2014.06.019
γ-干扰素释放试验诊断结核分枝杆菌感染相关研究meta分析
Interferon-γRelease Assay in Diagnosis of Tuberculosis Infection:a Meta-analysis
张昭勇 1张吉才 1吕军 1谢飞 1王元元1
作者信息
- 1. 442000 湖北 十堰，湖北医药学院附属太和医院检验部
- 折叠
摘要
Abstract
Objective To evaluate the application value of interferon-γrelease assays ( IGRA) in diagnosis of myco-bacterium tuberculosis infection. Methods All Chinese studies about IGRA in diagnosis of mycobacterium tuberculosis infec-tion during January 1994 and June 2013 were retrieved from CbmWin, CNKI and Wanfang databases. Two researchers a-chieved studies screening and data fetch independently, and then data analysis were conducted by meta-Disc1. 4 software after discrepancy studies were removed. Results Seventeen studies with 1799 patients and 885 controls were included in this stud-y. The results of meta-analysis showed that the sensitivity of mycobacterium tuberculosis was 86% [95% confidence interval (CI) :0. 85-0. 88];specificity was 86% (95% CI:0. 83-0. 88); positive likelihood ratio (LR) was 6. 06 (95% CI:4.76-7.70);negative LR was 0. 12 (95% CI: 0. 09 -0. 18) and diagnosis odds ratio (DOR) was 58. 67 (95% CI:35.37-97.31). Area under the curve (AUC) of fitting the summary receiver operating characteristic (SROC) was 0. 9457 and Q* =0. 8848. Conclusion Whole-blood interferon-γ release assays has good sensitivity and specificity in diagnosis of mycobacterium tuberculosis infection, and can be used as an effective method in clinical diagnosis of TB.关键词
干扰素γ释放试验/结核分枝杆菌/感染/诊断/meta分析Key words
Interferon-γ release assay/Mycobacterium tuberculosis/Infection/Diagnosis/Meta-analysis分类
医药卫生引用本文复制引用
张昭勇,张吉才,吕军,谢飞,王元元..γ-干扰素释放试验诊断结核分枝杆菌感染相关研究meta分析[J].临床误诊误治,2014,(6):41-44,4.
