临床误诊误治Issue(6)：95-98,4.DOI:10.3969/j.issn.1002-3429.2014.06.037
二甲双胍对2型糖尿病患者血浆C反应蛋白和血脂水平影响
Influence of Metformin on Serum C-reactive Protein and Lipid Level in Patients with Type 2 Diabetes Mellitus
摘要
Abstract
Objective To observe the changes of serum C-reactive protein (CRP) and lipid level before and after Metformin therapy in patients with type 2 diabetes mellitus. Methods A total of 84 patients with primary type 2 diabetes mel-litus were randomly divided into treatment group (n=42) and control group (n=42). The two groups received individual di-et, exercise scheme and oral Gliclazide Modified Release tablets, and the treatment group was added with Metformin based on the treatment. Changes of serum CRP and lipid level before treatment and after 36 and 72 weeks of treatment in the two groups were observed. Results After 36 and 72 weeks of treatment, levels of serum CRP, total cholesterol (TC), triglyceride ( TG) and low density lipoprotein cholesterol ( LDL-C) were significantly lower in treatment group, compared with those before treatment and in control group (P<0. 05);the level of high density lipoproteins (HDL-C) was significantly higher, compared with those before treatment and in control group (P<0. 05);the differences in levels of serum CRP, TC, LDL-C and HDL-C showed no statistical significances in control group before and after the treatment (P>0. 05). Conclusion Metformin can relieve IGT vascular inflammatory reaction and reduce the concentration of serum lipid level in patients with type 2 diabetes mellitus.关键词
糖尿病,2型/二甲双胍/C反应蛋白/血脂Key words
Diabetes mellitus, type 2/Metformin/C-reactive protein/Blood fat分类
医药卫生引用本文复制引用
苏宏,孙萌萌,赵跃萍,胡晓芳..二甲双胍对2型糖尿病患者血浆C反应蛋白和血脂水平影响[J].临床误诊误治,2014,(6):95-98,4.基金项目
辽宁省自然科学基金资助项目(201102240) （201102240）
