摘要
Abstract
Objective To review the effectiveness of omega-3 polyunsaturated fatty acids in the treatment of chronic heart failure. Methods The documents of randomized controlled trials ( RCT) related to the treatment of chronic heart failure withω-3 polyunsaturated fatty acids published during 1990 and 2014 were retrieved from the databases of CNKI, CBM, VIP, PubMed, Cochrane and Embase. The documents were screened, extracted and evaluated according to inclusion and exclusion criteria, and a meta-analysis was performed by using RevMan 5. 1 software. Results In total there were 4 RCT (7149 pa-tients) , in which 3583 cases were in test group, and 3566 cases were in the observation group. Through the quality assessment of literature, there were three articles of class B and one article of class A. 3 papers reported left ventricular ejection fraction ( LVEF) and brain natriuretic peptide ( BNP) , and 2 papers reported tumor necrosis factor-alpha ( TNF-α) and all-cause mor-tality rate. The results of meta-analysis showed as follows: the differences of LVEF, BNP and TNF-α between the two groups were significant (MD=0. 85, 95%CI:0. 10-1. 61, P=0. 03;MD= -169. 20, 95%CI:-208. 77-129. 63, P<0. 00001;MD=0. 32, 95%CI:0. 20-0. 43, P<0. 00001). While its influences on all-cause mortality rate showed no statistical difference be-tween the two groups (OR=0. 91, 95%CI:0. 81-1. 02, P=0. 10). Conclusion Omega-3 polyunsaturated fatty acids can sig-nificantly improve heart function and vascular inflammatory status in the patients with chronic heart failure, but not reduce the all-cause mortality of patients.关键词
ω-3多不饱和脂肪酸/心力衰竭/meta分析Key words
Fatty acids, omega-3/Heart failure/Meta-analysis分类
医药卫生
