临床误诊误治Issue(12)：74-77,4.DOI:10.3969/j.issn.1002-3429.2014.12.031
慢性阻塞性肺疾病患者牙周病及外周血、龈沟液炎性标志物观察
Oral Hygiene Status and Observation of Inflammatory Factors in Peripheral Blood and Gingival Crevicular Fluid of Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To compare the oral hygiene status and the observation of inflammatory factors in the peripher-al blood and gingival crevicular fluid (GCF) of chronic obstructive pulmonary disease (COPD). Methods 51 COPD pa-tients and 57 healthy controls were selected from the outpatient department and wards of Department Respiratory Diseases of the Fourth Affiliated Hospital of China Medical University during January 2012 to October 2013. Periodontal examination and measurements of inflammatory factors, including IL-1β, IL-6, TNF-αand hs-CRP, in the peripheral blood and GCF were de-tected in the two groups. Results The periodontitis prevalence of COPD group (56. 86%, n=29) was significantly higher than that of control group (21. 05%, n=12) (χ2 =14. 66, P<0. 01). The clinical attachment loss, periodontal probing depth, gingival index, sulcular bleeding index, plaque index, tooth mobility, dental fillings index and simplified oral hygiene index of the COPD group were significantly lower than those of the control group (P<0. 05). IL-1β, IL-6, TNF-α and hs-CRP in the peripheral blood of COPD group were notably higher than those of the control group;in addition, the GCF, IL-1β, IL-6 and TNF-α in the COPD group were still higher than those of control group (P<0. 05). Conclusion The oral hygiene status is poor in COPD patients, which increases the prevalence of periodontal disease. Therefore the expression levels of in-flammatory factors in peripheral blood and GCF are significantly increased.关键词
肺疾病,慢性阻塞性/牙周疾病/炎性因子/外周血/龈沟液Key words
Chronic obstructive pulmonary disease/Periodontal disease/Inflammatory factor/Peripheral blood/Gin-gival crevicular fluid分类
医药卫生引用本文复制引用
李方治,侯春阳,王笑歌..慢性阻塞性肺疾病患者牙周病及外周血、龈沟液炎性标志物观察[J].临床误诊误治,2014,(12):74-77,4.基金项目
“十一五”国家科技支撑计划(2009BAI18B02) （2009BAI18B02）
