临床误诊误治Issue(1)：91-94,4.DOI:10.3969/j.issn.1002-3429.2015.01.035
不同剂量瑞舒伐他汀钙治疗冠状动脉慢血流的临床效果研究
A Clinical Study on the Effect of Different-Dose Rosuvastatin Therapy on Coronary Slow Flow
摘要
Abstract
Objective To evaluate the effect of different-dose rosuvastatin therapy on coronary slow flow (CSF). Methods 90 patients were enrolled in our hospital during Jan 2010 and Jan 2013, diagnosed as having coronary slow flow by coronary angiography. They were randomized into high dose rosuvastatin group ( high dose group) , low dose rosuvastatin group ( low dose group) and control group ( n=30 each) . Rosuvastatin 20 mg/d, rosuvastatin 10 mg/d and placebo were given to the first two groups and the control group was only given conventional therapy. The course of the therapy was 4 weeks and M-TFC value was used to compare the coronary blood flow among different groups. The effect rates of therapies on angina in different groups were also evaluated. Results 4 weeks after treatment, level of M-TFC in all the groups were decreased sig-nificantly. Levels of M-TFC in both high dose group and low dose group were significantly lower than that in control group, and the level in high dose group was significantly lower than that in low dose group (P<0. 01). The effect rates of high dose group and low dose group were significantly higher than that of control group (χ2 =6. 2388, P=0. 0125; χ2 =4. 8000, P=0. 0285). There was no difference in the effect rates between high dose group and low dose group (χ2 =0. 0113, P =0. 7386 ) . Conclusion For patients with coronary slow flow, rosuvastatin therapy, based on the conventional medication, can significantly improve the coronary blood flow velocity and increase the effect rate in treatment of angina. Intensive rosuvastatin therapy with 20 mg/d is more effective for the patients with coronary slow flow.关键词
瑞舒伐他汀钙/冠状动脉疾病/血流速度/冠状动脉造影Key words
Rosuvastatin/Coronary artery disease/Blood flow velocity/Coronary angiography分类
医药卫生引用本文复制引用
叶廖沙,石宇杰,李俊峡,张健,孙琪..不同剂量瑞舒伐他汀钙治疗冠状动脉慢血流的临床效果研究[J].临床误诊误治,2015,(1):91-94,4.基金项目
吴阶平医学基金(320.6700.1173) （320.6700.1173）
