临床小儿外科杂志Issue(4)：271-274,4.DOI:10.3969/j.issn.1671-6353.2014.04.003
中国汉族人群AR基因多态性与男性尿道下裂的相关性研究
The CAG repeat polymorphism in the Androgen Receptor gene regulates the risk of hypospadias in ChineseHan population
摘要
Abstract
Objetive To analyze the risk for hypospadias in Han Chinese modified by the CAG repeat polymorphismintheexon1ofAndrogenReceptorgene.Methods DNAwasextractedformperipheralblood samples which came from 342 cases with hypospadias and 351 healthy voluntary anonymous blood sample do-nors.The CAG repeat lengths were amplified with PCR,which were calculated the difference between the hy-pospadiasandcontrolgroupusingChi-squaretest.Results ThemeanlengthofCAGinhypospadiaswas 23.65 ±3.36 (range 1 5 ~44),and it was 23.1 4 ±1 .87 (range 1 9 ~31 )in control group.A significant in-crease of the CAG repeat length in hypospadias group was detected when compared with the controls (P=0.01 3 ).In addition,the odds ratios between the hypospadias and controls revealed that the hypospadias cases are about 1 .5 times to have longer CAG repeats than a shorter length for each repeat length investigated. Con-clusion WehaveinvestigatedalargenumberofhypospadiascaseswithregardstotheCAGrepeatlength,and we provided evidence that a higher number of the CAG repeat sequence in the AR gene have a clear effect on the risk of hypospadias in Han Chinese.关键词
尿道下裂/受体,雄激素/基因/研究Key words
Hypospadias/Receptors,Androgen/Genes/Research引用本文复制引用
沈晓伟,徐卯升,林厚维,方晓亮,徐国锋,唐耘熳,耿红全..中国汉族人群AR基因多态性与男性尿道下裂的相关性研究[J].临床小儿外科杂志,2014,(4):271-274,4.基金项目
国家自然科学基金项目（项目号81170639）。 （）
