临床眼科杂志Issue(4)：336-339,4.DOI:10.3969/j.issn.1006-8422.2014.04.016
2型糖尿病患者糖尿病视网膜病变与 C-反应蛋白及代谢综合征关系的研究
The relationships between diabetic retinopathy, C-reactive protein (CRP) and metabolic syndrome
摘要
Abstract
Objective To observe and analyze the relationship between diabetic retinopathy ( DR), C-reactive protein ( CRP) and metabolic syndrome ( MS) .Methods Totally 183 patients with type 2 diabetes mellitus were included in this study.Subjects were divided into the two groups according to whether DR presented (observation group, n =101) or did not present (control group, n =82).Serum CRP level, routine metabolism indexes, and the prevalence of MS in the two groups were compared.Results Patients in the observation group, i.e., presented with DR, showed significantly higher levels of serum biomarkers including CRP , HbA1c, triglyceride and total cholesterol ( P <0.05).Not surprising-ly, the prevalence of MS and dyslipidemia were also higher in the patients with DR ( P <0.05).Furthermore, CRP and HbA1c levels were significantly higher in patients with more advanced DR than in patients with milder DR ( P <0.05). Multivariate logistic regression analysis showed that the triglyceride (OR=1.520) and CRP (OR=2.376) were positively correlated with the incidence of DR ( P <0.05).Conclusion Increased HbA1c and presence of MS or dyslipidemia may be the risk factors of DR.The high CRP and high triglyceride levels are independent risk factors of DR .CRP and HbA1c may be correlated with the severity of DR .Clinicians should employ early interventions among patients with these high risk factors in order to improve the outcomes of DR .关键词
2型糖尿病/糖尿病视网膜病变/C-反应蛋白/代谢综合征Key words
Type 2 diabetes mellitus/Diabetic retinopathy/C-reactive protein/Metabolic syndrome引用本文复制引用
刘宁,曹西友,褚俏梅,杜乔乔..2型糖尿病患者糖尿病视网膜病变与 C-反应蛋白及代谢综合征关系的研究[J].临床眼科杂志,2014,(4):336-339,4.
