临床眼科杂志Issue(2)：130-134,5.DOI:10.3969/j.issn.1006-8422.2015.02.011
雷珠单抗联合格栅样光凝治疗视网膜分支静脉阻塞引起的黄斑水肿疗效观察
Comparison of clinical efficacy of intravitreal ranibizumab with and without grid laser photocogagulation for macular edema secondary to branch retinal vein occlusion
徐晓芳 1何芳邻 1姜婧 1王静 1张艺丹 1范先群1
作者信息
- 1. 200011 上海，上海交通大学医学院附属第九人民医院眼科
- 折叠
摘要
Abstract
Objective To compare the short-term efficacy and safety of intravitreal ranibizumab ( IVR) or IVR combined with grid laser photocogagulation ( GLP) for macular edema ( ME) secondary to branch retinal vein occlusion ( BRVO) .Methods 28 newly diagnosed patients with ME secondary to BRVO were divided into two groups randomly:one group was treated with IVR and the other group was treated with IVR and GLP.Patients were followed up at 1, 2, 3, 4, 5, 6 months, best corrected visual acuity (BCVA), changes in BCVA and central macular thickness (CMT) were com-pared in each phase and between groups.Results At month 6, BCVA change from baseline was 9.0 ±2.6 letters in the IVR group ( P =0.004) and 12.3 ±3.2 letters in the IVR+GLP group ( P =0.013).Mean CRT changes were 179.4 ±20.8 μm in the IVR group and 202.7 ±15.9 μm in the IVR+GLP group ( P =0.0001).There were nostatistically significant differences in BCVA or CRT changes between groups ( P﹥0.05).The number of intravitreal injections was significantly higher in the IVR group (3.2 ±1.1 injections) than in the IVR+GLP group (1.9 ±1.0 injections, P =0.002 ) .There were no serious side-effects in both groups.Conclusions IVR or IVR +GLP had similar effects on BCVA and CMT in patients with ME secondary to BRVO over a 6-month follow-up period.IVR+GLP is more affordable and toler-able for patients because of less intravitreal injections.关键词
雷珠单抗/格栅样光凝/黄斑水肿/视网膜分支静脉阻塞Key words
Ranibizumab/Grid laser photocogagulation/Macular edema/Branch retinal vein occlusion引用本文复制引用
徐晓芳,何芳邻,姜婧,王静,张艺丹,范先群..雷珠单抗联合格栅样光凝治疗视网膜分支静脉阻塞引起的黄斑水肿疗效观察[J].临床眼科杂志,2015,(2):130-134,5.
