临床与实验病理学杂志Issue(4)：419-422,4.DOI:10.13315/j.cnki.cjcep.2014.04.016
乳头状胶质神经元肿瘤3例临床病理学分析
Papillary glioneuronal tumor:a clinicopathologic analysis of three cases
张安莉 1李恒 1丁敏2
作者信息
- 1. 安徽省立医院南区病理科，合肥 230036
- 2. 安徽省立医院病理科，合肥 230001
- 折叠
摘要
Abstract
Purpose To investigate clinicopathological features, immunohistochemical findings and differential diagnosis of papillary glioneuronal tumor ( PGNT) . Methods The clinical features, imaging, histological and immunohistochemical findings were analyzed in three cases of PGNT, along with review of the related literatures. Results Two patients were female adults, and the other was male adults. One presented with dizziness, and the other exhibited intractable seizures. Magnetic resonance imaging ( MRI) revealed a cyst-ic space-occupying mass in brain parenchyma of left temporal lobe or right parietal lobe. Microscopically, it was characterized by pseu-dopapillary structures composed of hyalinized vessels rimmed by cuboidal glial cells, oligodendrocyte-like cells and the proliferation of neuronal cells. On immunohistochemical staining, the perivascular cuboidal cells were GFAP-positive, the oligodendrocyte-like cells were Olig-2-positive, and the neuronal cells were synaptophysin-and nuclear protein-positive. Conclusion PGNT is a rare and new variant of mixed neuronal-glial neoplasm, the natural evolution of this tumor is one of low malignant potential and it has a good progno-sis. The distinctive pathologic features help to differentiate this entity from other neoplasm of the central nervous system which has pa-pillary structures.关键词
乳头状胶质神经元肿瘤/神经元-胶质混合性肿瘤/临床病理Key words
papillary glioneuronal tumor/mixed neuronal-glial tumor/clinicopathology分类
医药卫生引用本文复制引用
张安莉,李恒,丁敏..乳头状胶质神经元肿瘤3例临床病理学分析[J].临床与实验病理学杂志,2014,(4):419-422,4.
