临床与实验病理学杂志Issue(9)：983-986,4.DOI:10.13315/j.cnki.cjcep.2014.09.009
子宫颈原发性淋巴上皮瘤样癌8例临床病理分析
Clinic-pathologic characteristics of lymphoepithelioma-like carcinoma in cervix
左敏 1胡锦涛 1郭晓静 1陈灼怀1
作者信息
- 1. 广东省深圳市人民医院病理科 518020
- 折叠
摘要
Abstract
Purpose To study the clinic-pathologic features, differential diagnosis and prognosis of lymphoepithelioma-like carcinoma of cervix. Methods Eight cases of lymphoepithelioma-like carcinoma of cervix were retrieved from our institution. HE staining, im-munohistochemistry and in situ hybridization were perform on those cases. Results Of the 8 cases of lymphoepithelioma-like carcino-ma,the median age was 44 years old ( ranged from 29-67 years) and all of the clinical stage belonged toⅠB. Grossly, 5 cases presen-ted a cauliflower-like appearance, 1 case grew as a polyp protrusion, and the other 2 cases showed a non-specified thicken change of cervix. Histologically, the tumors were composed of undifferentiated large cells, either loosely or closely-packed, with the nested and trabecular growth pattern. The tumor cells were generally oval or polygonal in shape, while the demarcation between the cells was indis-tinct and form the syncytial appearance. The nuclei were vesicular and had one or more prominent nucleoli. There were abundant infil-trates of lymphocyte and plasma cells among the tumor nests. The tumor cells showed positive expression of CK in 100% of cases, p63 in 37. 5% of cases, p16 in 62. 5% of cases, CK5/6 in 75% of cases, Ki-67 in 10% ~30% of cases. The stromal lymphocytes mainly expressed CD3 and CD8. EBER was negative in the entire tumor cells while was weakly positive in the stromal lymphocytes in one case. The follow-up data, which terminated at June 2013, demonstrate 7 cases were alive and 1 case died of the disease. Conclusions Lymphoepithelioma-like carcinoma occurred of cervix is rare. They have distinctive morphologic features and overall favorable prog-nosis. The accurate diagnosis is dependant on the combination of the histologic and immunohistochemical examination.关键词
子宫颈肿瘤/原发性淋巴上皮瘤样癌/临床病理Key words
uterine cervical neoplasm/primary lymphoepithelioma-like carcinoma/clinic-pathologic features分类
医药卫生引用本文复制引用
左敏,胡锦涛,郭晓静,陈灼怀..子宫颈原发性淋巴上皮瘤样癌8例临床病理分析[J].临床与实验病理学杂志,2014,(9):983-986,4.
