临床与实验病理学杂志Issue(9)：991-995,999,6.DOI:10.13315/j.cnki.cjcep.2014.09.011
原发性性腺外卵黄囊瘤40例临床病理分析
Primary extragonadal yolk sac tumor:a clinicopathologic analysis of 40 cases
曹钟 1钟佳良 2朱贤海 3杨志勇 4敖启林5
作者信息
- 1. 湖北省黄冈市中心医院病理科，黄冈 438000
- 2. 湖北省黄冈市中心血站，黄冈 438000
- 3. 河南省商城县人民医院病理科，商城 465316
- 4. 湖北省黄冈市中心医院放疗中心，黄冈 438000
- 5. 华中科技大学同济医学院附属同济医院病理研究所/同济医学院病理学系，武汉 430030
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathological features, histogenesis, morphological characteristics, immunophenotypes and differential diagnosis of primary extragonadal yolk sac tumor ( eYST) . Methods Clinicopathological data, morphological charac-teristics and immunophenotypes results of 40 cases of eYST were retrospectively studied and the relevant literatures were reviewed. Re-sults All 40 patients, which included 24 male and 16 female, aged from 6 months to 42 years with a 12 years average age and 17 (42.5%) cases were over 12 years old. Mediastinum, sacrococcygeal, retroperitoneal, pineal gland and vagina were involved in 16 (40.0%), 12(30.0%), 5(12.5%), 4(10.0%) and 3(7.5%), respectively. All 40 cases included 32(80.0%) cases pure YSTs, while other 8(20.0%) cases contained other one or two types of germ cell tumor (GCT) components. Conclusions Primary eYST is rare, mediastinum and sacrococcygeal are the most common anatomic sites for eYST, and these mediastinal tumor patients are overwhelmingly confined to adult males, whose average age are significantly older than that in sacrococcygeal, retroperitoneal, pineal gland and vaginal tumor patients (P<0.05), while other sites eYST are restricted to prepubertal children. Adult eYST contain other types of GCT components in some cases, and children's counterparts are always pure YST. Extragonadal eYST manifestate pleomorphic histological features, which combine with immunohistochemical markers is definite value for diagnosis, differential diagnosis.关键词
卵黄囊瘤/性腺外/临床病理学/免疫组织化学Key words
yolk sac tumor/extragonadal/clinicopathology/immunohistochemistry分类
医药卫生引用本文复制引用
曹钟,钟佳良,朱贤海,杨志勇,敖启林..原发性性腺外卵黄囊瘤40例临床病理分析[J].临床与实验病理学杂志,2014,(9):991-995,999,6.
