临床与实验病理学杂志Issue(9)：1007-1010,4.DOI:10.13315/j.cnki.cjcep.2014.09.015
IgA肾病高尿酸血症与牛津病理分型及临床特征
Clinical characteristics and Oxford classification of IgA nephropathy patients with hyperuri-cemia
张炜 1吴永贵 1梁维龙 1江肖 1王喆 1徐兴欣1
作者信息
- 1. 安徽医科大学第一附属医院肾脏内科，合肥 230032
- 折叠
摘要
Abstract
Purpose To investigate the clinical characteristics and Oxford classification of IgA nephropathy patients with hyperurice-mia. Methods 151 IgA nephropathy patients confirmed by renal biopsy in 2013 were analyzed retrospectively. The patients were di-vided into the two groups:IgA nephropathy patients with or without hyperuricemia. Morphological changes were evaluated with Oxford classification scoring system and Lee’s grades. A comparative analysis of clinical manifestations and pathological injuries was performed between the two groups. Results Incidence of hyperuricemia in IgA nephropathy patients was 48. 3% and was more common in young men. Hypertension was associated with hyperuricemia. Oxford classification of IgA nephropathy patients with hyperuricemia was pre-dominant M1E0S1T0 and Lee’s grades presented with grade Ⅲ. The outstanding histopathologic features with higher plasma uric acid levels indicated higher tubulointerstitial chronicity, higher glomerular sclerosis ratio, accompanied by a decline in glomerular filtration rate. There was no significant difference of vascular lesions. Conclusions The prevalence of hyperuricemia in IgA nephropathy pa-tients is high. Oxford classification shows IgA nephropathy with hyperuricemia are associated with more severe tubulointerstitial lesions and lower GFR.关键词
IgA肾病/高尿酸血症/肾脏病理/牛津病理分型Key words
IgA nephropathy/hyperuricacidemia/kidney pathology/Oxford classification分类
医药卫生引用本文复制引用
张炜,吴永贵,梁维龙,江肖,王喆,徐兴欣..IgA肾病高尿酸血症与牛津病理分型及临床特征[J].临床与实验病理学杂志,2014,(9):1007-1010,4.
