临床与实验病理学杂志Issue(11)：1228-1231,1236,5.DOI:10.13315/j.cnki.cjcep.2014.11.007
子宫颈鳞状细胞癌组织中LC3B的表达及其与Ki-67表达的相关性
Expression of LC3B in cervical squamous carcinoma and its relationship with Ki-67 expression
摘要
Abstract
Purpose To investigate the expression of autophagy-related protein LC3B in cervical squamous carcinoma and its relation-ship with Ki-67 expression. Methods To detect the expression of LC3B in 16 cases of normal cervical tissues and 126 cases of squa-mous cell carcinoma by immunohistochemical staining. In addition, Ki-67 protein was also detected in 126 cases of squamous cell car-cinoma in the same assay. The relationship between LC3B expression and Ki-67 in cervical squamous cell cancer was statistical analy-sis. Results Expression level of LC3B were significantly lower in cervical squamous carcinoma than normal squamous epithelial cells (P<0. 05), and the expression of LC3B was negatively correlated with Ki-67(rs = -0. 248, P<0. 05). Conclusion It appears that decreased levels of autophagy which indicated by low expression of LC3B may promote cancer cell proliferation in the early stages of cervical squamous cell carcinoma, which provides a clinical referential evidence for further explore the mechanism of autophagy in cer-vical cancer development.关键词
子宫肿瘤/鳞状细胞癌/LC3B/Ki-67/自噬/免疫组织化学Key words
uterine neoplasm/squamous cell carcinoma/LC3B/Ki-67/autophagy/immunohistochemistry分类
医药卫生引用本文复制引用
赵洪萍,周颖,万安,赵卫东..子宫颈鳞状细胞癌组织中LC3B的表达及其与Ki-67表达的相关性[J].临床与实验病理学杂志,2014,(11):1228-1231,1236,5.基金项目
国家自然科学基金(81272881)、安徽省2014年度重点立项项目(130104053) （81272881）
