临床与实验病理学杂志Issue(12)：1368-1370,1374,4.DOI:10.13315/j.cnki.cjcep.2014.12.010
非小细胞肺癌中DLL4蛋白的表达及其临床意义
Expression of DLL4 in NSCLC and and its clinical significance
摘要
Abstract
Purpose To assess the expression of DLL4 in non-small cell lung cancer ( NSCLC) patients and to determine its associa-tion with clinicopathological parameters and prognosis. Methods DLL4 expression was evaluated in NSCLC tissues and adjacent non-cancerous normal lung tissues from 89 patients undergoing surgical treatment by immunohistochemistry. Results DLL4 had high ex-pression in 52 of 89 cases of NSCLC (58. 4%), which was significantly higher than that in adjacent non-cancerous lung tissues (P<0. 05). Moreover, DLL4 overexpression was significantly correlated with TNM stage (P=0. 010 78). Kaplan-Meier survival analysis showed that the overall survival times in patients expressing DLL4 in NSCLC were shorter. Conclusion High level of DLL4 expression is significantly correlated with NSCLC progression and unfavorable prognosis. Thus, DLL4 expression may be used as a clinical param-eter for predictive prognostication of NSCLC patients.关键词
肺肿瘤/NSCLC/DLL4/预后/免疫组织化学Key words
lung neoplasms/non-small cell lung cancer/DLL4/prognosis/immunohistochemistry分类
医药卫生引用本文复制引用
陈梅莉,钱震东,叶元滋,张妍蓓..非小细胞肺癌中DLL4蛋白的表达及其临床意义[J].临床与实验病理学杂志,2014,(12):1368-1370,1374,4.基金项目
安徽省教育厅重点项目(KJ2011A178)、安徽省科技厅自然基金重点项目(1208085MH146) （KJ2011A178）
