临床与实验病理学杂志Issue(1)：19-23,28,6.DOI:10.13315/j.cnki.cjcep.2015.01.005
卵巢成熟性畸胎瘤恶变22例临床病理分析
Malignant transformation in mature teratoma of the ovary：a clinicopathologic study of 22 cases
杨旭丹 1王雷 1王晓卿 1傅静 1刘裔莎 1张潇潇 2廖治 2徐钢1
作者信息
- 1. 四川省医学科学院·四川省人民医院病理科，成都 610072
- 2. 四川省医学科学院·四川省人民医院妇产科，成都 610072
- 折叠
摘要
Abstract
Purpose To study the clinicopathological characteristics in 22 cases of ovarian mature teratoma with malignant transforma-tion. Methods Clinical and pathologic features were collected and analyzed in 22 out of 1 826 cases of ovarian mature teratoma by retrospective studies, together with immunohistochemical staining. Results In our study, 22 cases (1. 2%) of ovarian mature terato-ma with malignant transformation were identified. The median age was 56. 5 (range, 31~79) years. The main clinical manifestations were pelvic masses, including 13 cases in the left ovary, 8 cases in the right, 1 case was bilateral. Gross cystic teratoma were saw in 19 cases, 3 cases of cystic and solid, the bilateral one was solid in the left which the right was cystic. The teratomas size were 5. 0~30 cm with average 12. 4 cm in diameter. The malignant components’ maximum diameter was about 1. 0~10. 0 cm with average 3. 7 cm. Microscopicically, there were poorly differentiated squamous cell carcinoma in 14 cases, carcinoid carcinoma in 4 cases, adeno-carcinoma in 2 cases, papillary thyroid carcinoma in 2 cases, and the last one was sarcomatoid carcinoma. The FIGO stage distribution was as follows:16 were stage IA, 1 was stage IB, 1 was stage IIA, 4 were stage IIB. Follow up showed 6 cases recurrened, 2 patients died, the rest are survival. Conclusions A low incidence of ovarian mature teratoma in somatic cells with malignant transformation, which are common in postmenopausal women and present with pelvic mass. The main malignant components is squamous cell carcino-ma, patients of stage I have better prognosis. Both clinic and pathology should take more attention to the comprehensive examination and diagnosis of teratoma for prevent misdiagnosis.关键词
卵巢肿瘤/成熟性畸胎瘤/恶变/临床病理Key words
ovarian neoplasm/mature teratoma/malignant transformation/clinicopathologic features分类
医药卫生引用本文复制引用
杨旭丹,王雷,王晓卿,傅静,刘裔莎,张潇潇,廖治,徐钢..卵巢成熟性畸胎瘤恶变22例临床病理分析[J].临床与实验病理学杂志,2015,(1):19-23,28,6.
