临床与实验病理学杂志Issue(2)：154-156,160,4.DOI:10.13315/j.cnki.cjcep.2015.02.009
胃原发性淋巴上皮瘤样癌6例临床病理学观察
Lymphoepithelioma-like gastric carcinoma:a clinicopathologic study of six cases
摘要
Abstract
Purpose To investigate the clinicopathologic features and immunophenotype as well as its association with EBV infection of lymphoepithelioma-like gastric carcinoma (LLGC). Methods The clinical pathological data were reviewed, morphological changes were observed and immunohistochemical staining was done in 6 cases of LLGC. The expression of EBV-encoded small RNA ( EBER) in the 6 cases of LLGC were carried out by in situ hybridization. Results All of the six patients were male, the age was arranged 47 to 68 years, with mean of 55 years. All of the six cases, the lesions were located in gastric body. Microscopically, the undifferentiated carcinoma cells were arranged in cords and nests, scattering in the lymphoid-rich stroma, occasionally poor development tubular struc-tures were seen in the near surface of mucosa. Lymphoid follicles could be seen with lack of fibrous tissues reaction in the tumor stro-ma. Immunohistochemical staining and in situ hybridization showed the tumor cells were diffusely positive for CKpan, CK19, CEA and EBER, but negative to CK7, CK20, CK5/6 and LMP1; interstitial lymphocytes expressed CD3 or CD20, while lost expression of EBER. Follow-up for 6-57 months, all of the 6 patients were survived without tumor. Conclusions The LLGC is a rare and unique subtype of gastric carcinoma with good prognosis, which is often associated with EBV infection.关键词
胃肿瘤/淋巴上皮瘤样癌/临床病理/EB病毒Key words
gastric neoplasms/lymphoepithelioma-like gastric carcinoma/clinicopathological features/EB virus分类
医药卫生引用本文复制引用
莫超华,温宗华,莫祥兰,刘冰薇,梁劲劲..胃原发性淋巴上皮瘤样癌6例临床病理学观察[J].临床与实验病理学杂志,2015,(2):154-156,160,4.基金项目
国家自然科学基金(81360355)、广西卫生厅科研课题(Z2013355) （81360355）
