临床与实验病理学杂志Issue(2)：164-168,5.DOI:10.13315/j.cnki.cjcep.2015.02.012
胃炎性肌纤维母细胞肿瘤的临床病理观察
Primary gastric inflammatory myofibroblastic tumor:a clinicopathologic study
刘毅强 1徐丹 2黄小征 1周立新 1薛卫成1
作者信息
- 1. 北京大学肿瘤医院暨北京市肿瘤防治研究所病理科/恶性肿瘤发病机制及转化研究教育部重点实验室，北京100142
- 2. 湖北省松滋市人民医院病理科，松滋 434200
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathologic features, diagnosis and differential diagnosis of primary gastric inflammatory myofibroblastic tumor ( IMT) . Methods Four cases of gastric IMTs were studied by clinicopathologic analysis, immunohistochemistry and in situ hybridization, and the related literature was reviewed. Results In four cases there are two males and two females, age range from 21 to 51 years old, and tumor size ranged from 1. 5 to 6. 5 cm in the greatest dimension. Histologically, these tumors were composed of varied spindle cells and chronic inflammatory cells, in a myxoid or hyalinized stroma. Occasionally, there were calcifica-tion and ossification areas. Most of the spindle cells had bland appearance and a minority of the tumor cells showed mild atypia. One to two mitotic figures were recognized in 10 high power fields ( HPFs) in 1 to 2 patients. Smooth muscle actin staining was observed in all tumors and ALK staining observed in two tumors. One tumor focally expressed CD34. S-100, desmin, CD68, CD117 and DOG1 was negative in all IMTs. The patients were followed up from 24 to 66 months, and none of them had tumor relapsed or metastasis. Conclu-sions Primary gastric IMTs have an intermediate behavior, and a few cases have malignant potential. It should be distinguished from other spindle cell lesions similar to IMT.关键词
胃肿瘤/炎性肌纤维母细胞肿瘤/临床病理/鉴别诊断Key words
gastric neoplasms/inflammatory myofibroblastic tumor/clinicopathology/differential diagnosis分类
医药卫生引用本文复制引用
刘毅强,徐丹,黄小征,周立新,薛卫成..胃炎性肌纤维母细胞肿瘤的临床病理观察[J].临床与实验病理学杂志,2015,(2):164-168,5.
