临床与实验病理学杂志Issue(3)：260-263,4.DOI:10.13315/j.cnki.cjcep.2015.03.005
食管胃交界部腺癌中CD151、MT1-MMP的表达及意义
Expression of CD151 and MT1-MMP in adenocarcinoma of esophagogastric junction and their significances
苗杰 1郭秀芳 2许欣 1姚冬颖 1刘晓丽 1齐蕾 1付琳 1李永才3
作者信息
- 1. 河北医科大学附属邢台人民医院病理科，邢台 054001
- 2. 邢台医学高等专科学校附属第一医院病理科，邢台054001
- 3. 河北医科大学附属邢台人民医院CT/MRI科，邢台 054001
- 折叠
摘要
Abstract
Purpose To investigate the expression of the protein of CD151 and MT1-MMP in adenocarcinoma of esophagogastric junc-tion tissues and to explore their relationship with the invasiveness and metastasis of the tumor. Methods CD151 and MT1-MMP pro-tein were detected by immunohistochemical staining respectively in 15 cases of paraneoplastic normal gastric mucosa tissue, 40 cases dysplasia and 172 cases of adenocarcinoma of esophagogastric junction tissues. Results All of the expression level of CD151 and MT1-MMP protein were increasing according to the order of normal-dysplsia-carcinoma. The expression rate of CD151 was 6. 67%, 20. 0% and 78. 3%, while the rate of MT1-MMP with 13. 3%, 22. 5% and 79. 1% in the normal, dysplasia and carcinoma subgroup. The expression rate of each protein were significant difference among the three goroups (P<0. 05). In the adenocarcinoma of esopha-gogastric junction tissues, the expression of them in the subgroup of poorly-differentiated with serosa invasion and lymph nodes metasta-sis was significantly higher than the other subgroup of well-differentiated with non serosa invasion or lymph nodes metastasis ( P <0. 05 ) . There was a positive correlation between the expression of CD151 and MT1-MMP protein in adenocarcinoma of esophagogastric junction tissues ( P<0. 05 ) . Conclusions CD151 and MT1-MMP assuredly and highly express in the adenocarcinoma of esopha-gogastric junction tissues and they have close relationships, which could involved in the invasiveness and metastasis synergistically in this tumor.关键词
胃肿瘤/食管胃交界部/CD151/MT1-MMP/免疫组织化学Key words
stomach neoplasm/gastroesophageal junction/CD151/MT1-MMP/immunohistochemical分类
医药卫生引用本文复制引用
苗杰,郭秀芳,许欣,姚冬颖,刘晓丽,齐蕾,付琳,李永才..食管胃交界部腺癌中CD151、MT1-MMP的表达及意义[J].临床与实验病理学杂志,2015,(3):260-263,4.
