临床与实验病理学杂志Issue(3)：282-285,4.DOI:10.13315/j.cnki.cjcep.2015.03.010
卵巢透明细胞癌中HNF-1β的诊断价值
Diagnostic value of HNF-1βin the diagnosis of ovarian clear cell carcinoma
熊克美 1黄文斌 1王劲松 1李青 2程雪2
作者信息
- 1. 南京医科大学附属南京医院 南京市第一医院 病理科210006
- 2. 南京医科大学附属南京妇幼保健院病理科 210004
- 折叠
摘要
Abstract
Purpose To study the expression of HNF-1β in different type ovarian carcinoma and to explore the diagnostic value of HNF-1β in the diagnosis of ovarian clear cell carcinoma. Methods Immunohistochemical EnVision method was used to detect the ex-pression of HNF-1βin 27 clear cell carcinomas, 35 high-grade serous carcinomas, 21 endometrioid adenocarcinoma, 10 mucious carci-nomas, 13 metastatic Krukenberg tumors, and 2 transitional carcinomas. Results All of ovarian clear cell carcinomas variably ex-pressed HNF-1β and the positive rate of HNF-1β in ovarian cleat cell carcinoma was 85. 2%. Of 21 ovarian serous carcinomas, the nuclear positive of HNF-1β was 4 and HNF-1βpositive rate was 2. 9%. There was 5 HNF-1βexpression in endometrioid adenocarci-noma and the positive rate of HNF-1β was 23. 8%. The positive rate of HNF-1β in mucious carcinoma and metastatic Krukenberg tumor was 60. 0% and 53. 8%, respectively. No HNF-1βexpression was seen in transtional cell carcinoma. The sensitivity and speci-ficity of HNF-1β in the diagnosis of ovarian clear cell carcinoma was 85. 2% and 76. 5%. Conclusions HNF-1β may be a higher sensitive marker for the diagnosis of ovarian clear cell carcinoma. The diffuse and strong positive of HNF-1βmay have higher specific for diagnosis of ovarian clear cell carcinoma.关键词
卵巢肿瘤/透明细胞癌/HNF-1β/免疫组织化学Key words
ovarian neoplasm/clear cell carcinoma/HNF-1β/immunohistochemistry分类
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熊克美,黄文斌,王劲松,李青,程雪..卵巢透明细胞癌中HNF-1β的诊断价值[J].临床与实验病理学杂志,2015,(3):282-285,4.
