临床与实验病理学杂志Issue(4)：390-394,399,6.DOI:10.13315/j.cnki.cjcep.2015.04.008
乳腺浸润性小叶癌的临床病理特征
Clinicopathologic characteristics of invasive lobular carcinoma of the breast
李丽 1孟刚 1汪小霞 1王岳君 1杨苗苗 1陈青 1黄雯 1韩彪1
作者信息
- 1. 安徽医科大学病理学教研室，合肥 230032
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathological characteristics and the survival outcomes of invasive lobular carcinoma. Methods A retrospective analysis of 98 patients with invasive lobular carcinoma and 530 invasive carcinoma of no special type was performed in order to observe the histological features and the clinical outcomes of invasive lobular carcinoma. Results Median follow-up was 68. 5 months for invasive lobular carcinoma and 67 months for invasive carcinoma of no special type. Invasive lobular carcinoma presented with a larger tumor size, more histopathological grade 2 tumors, increased rate of hormonal receptor positivity, human epider-mal growth factor 2 (HER-2) negativity, and had a lower proliferative index as compared to invasive carcinoma of no special type, more frequently presented with the luminal A subtype (P<0. 001). The classical invasive lobular carcinoma presented with a smaller tumor size, to have a lower histological grade and proliferative index compared to the non-classic type, and more frequently presented with the luminal A subtype, whereas the non-classic invasive lobular carcinoma patients more frequently presented with the luminal B, HER-2 overexpression, or triple negative subtype (P=0. 035). A statistically significant difference in the outcome was observed at un-ivariate analysis for patients with non-classic for disease-free survival (P=0. 043) and for overall survival (P=0. 048), as compared with patients with classical invasive lobular carcinoma. The disease-free survival difference between the invasive lobular carcinoma and the invasive carcinoma of no special type was not significant (P=0. 537), and the overall survival rates were not statistically different between the two groups (P=0. 397). A statistically significant difference of overall survival was observed at multivariate analysis for patients with HER-2 positive and triple negative subtypes versus patients with luminal A invasive lobular carcinoma (P=0. 015, P=0. 016) . Conclusions The outcome of invasive lobular carcinoma is significantly correlated with histological and immunohistochemi-cally defined molecular subtypes. New tailored strategies should be explored in these subgroups of patients with poor outcome.关键词
乳腺肿瘤/浸润性小叶癌/非特殊型浸润性癌/临床病理特征/分子分型/预后Key words
breast neoplasms/invasive lobular carcinoma/invasive carcinoma of non-specific type/clinicopathologic characteristics/molecular subtype/outcome分类
医药卫生引用本文复制引用
李丽,孟刚,汪小霞,王岳君,杨苗苗,陈青,黄雯,韩彪..乳腺浸润性小叶癌的临床病理特征[J].临床与实验病理学杂志,2015,(4):390-394,399,6.
