临床与实验病理学杂志Issue(5)：528-531,4.DOI:10.13315/j.cnki.cjcep.2015.05.011
乳腺癌组织中TPX2蛋白的表达及其临床意义
Expression of TPX2 in breast cancer tissue and their clinical significances
摘要
Abstract
Purpose To investigate the expression of TPX2 in breast cancer, analyze the correlation between its expression and clinico-pathologic characteristics and explore the significances of TPX2 in the treatment and prognosis of breast cancer. Methods Expression of TPX2 in breast cancer tissues, adjacent tissue of cancer and normal breast tissue was examined by immunohistochenistry SP method. The mRNA expression of TPX2 in breast cancer tissues, adjacent tissue of cancer and normal breast tissue was detected by reverse-transcription polymerase chain reaction ( RT-PCR) . Results The expression of TPX2 is significantly higher in breast cancer tissues (75. 86%) compared with adjacent tissue of cancer (40. 00%) and normal breast tissue (5. 00%). And the expression of TPX2 cor-related with tumor grade and lymph node metastasis (P<0. 01), while unrelated to age and clinical stage (P>0. 05). The expression of TPX2 mRNA is also significantly higher in breast cancer tissues ( 1. 465 7 ± 0. 136 6 ) compared with adjacent tissue of cancer (0. 923 3 ±0. 114 8) and normal breast tissue (0. 326 9 ±0. 097 3) (P<0. 01). Conclusion High expression of TPX2 in breast cancer correlated with tumor grade and lymph node metastasis, so TPX2 might be a risk factor in the tumorigenesis, progression and lymph node metastasis in breast cancer.关键词
乳腺肿瘤/TPX2蛋白/TPX2 mRNA/免疫组织化学Key words
breast neoplasm/TPX2 protein/TPX2 mRNA/immunohistochemistry分类
医药卫生引用本文复制引用
张春梅,李敏,周仕娴..乳腺癌组织中TPX2蛋白的表达及其临床意义[J].临床与实验病理学杂志,2015,(5):528-531,4.基金项目
重庆市卫生局医学科研计划(2012-2-375) （2012-2-375）
