临床与实验病理学杂志Issue(7)：725-728,4.DOI:10.13315/j.cnki.cjcep.2015.07.002
乳腺肿瘤组织中GATA3的表达及临床意义
Expression of GATA3 in breast tumor and its clinical significance
摘要
Abstract
Purpose To investigate the expression of GATA3 in breast tumors and its clinical significance. Methods Immunohisto-chemistry EnVision method was used to detect the expression of GATA3 protein in 132 cases of breast malignant tumor tissue, 29 cases of breast benign tumor tissue, 35 cases of breast carcinoma adjacent tissue. Besides, the GATA3 expression level was compared with several clinicopathological parameters. Result (1) All the breast normal tissues expressed GATA3, while 77% of the breast cancer tissue were found to be GATA3 positive. (2) GATA3 did not expressed in diffuse large B cell lymphoma and spindle cell malignant tumor of breast. (3) In the triple negative breast cancer, the expression of GATA3 was lower than that of any other subtypes of breast carcinoma (χ2 =29. 354, P<0. 001). Conclusion The positive expression of GATA3 is correlated to classification and grade in breast tumor. Detection of the expression of this biological maker may provide a valuable marker for the differential diagnosis and prog-nostic of breast carcinoma.关键词
乳腺肿瘤/GATA3/免疫组织化学/病理诊断Key words
breast neoplasm/GATA3/immunohistochemistry/pathlogical diagnosis分类
医药卫生引用本文复制引用
程凯,周晓蝶,余波,王海,周晓军,石群立..乳腺肿瘤组织中GATA3的表达及临床意义[J].临床与实验病理学杂志,2015,(7):725-728,4.基金项目
南京军区南京总医院院管课题(2012045) （2012045）
