临床与实验病理学杂志Issue(7)：752-755,756,5.DOI:10.13315/j.cnki.cjcep.2015.07.008
6例分化型外阴上皮内瘤变临床病理观察
Clinicopathologic observation of 6 cases of differentiated-type vulvar intraepithelial neoplasia
张和平 1陈先侠 2解正新 1赵彩霞 1汪勤 1刘婷珽1
作者信息
- 1. 安徽医科大学妇幼保健临床学院/安徽省妇幼保健院 病理科，合肥 230001
- 2. 安徽医科大学妇幼保健临床学院/安徽省妇幼保健院 妇产科，合肥 230001
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathologic characteristics, differential diagnosis, treatment and prognosis of differentia-ted-type vulvar intraepithelial neoplasia ( dVIN) . Methods Clinicopathologic findings and immunophenotypes of 6 cases diagnosed as“dVIN” were retrospectively analyzed, and the relevant literatures were also reviewed. Results 6 patients were all female ranged 53~80 years old with mean age of 62 years old. Clinical aspects included leukoplakia vulvar, pruitis, irritation, pain, ulcer and so on. The histopathological features were hyperplasia of basal and parabasal layer with elongation and anastomosing reteridges. Cells were marked atypia with obvious nucleoli, atypical mitosis, and dyskeratosis. In the middle and surface layer, cells were well differentiated with pronounced intercellular bridges, and eosinophilic cytoplasm, hyperkeratosis and parakeratosis. Oedema and band of infiltration of chronic inflammatory cells of subepidermal could been seen. Immuohistochemistry showed the expression rates of p53 and p16 in totally 6 cases were 83. 3% (5/6), 0 (0/6), respectively. The Ki-67 index was more than 90% in basal and parabasal cells. Four patients were followed up ( mean follow-up 17 months, range 6~36 months) , one patient died at 9 months later after surgery, another patient recurred at 6 months later after surgery, both of the 2 cases were all with invasive lesions after resection, and the rest two cases had no recur in 18 months and 36 months after surgery, respectively. Conclusion dVIN is a high grade squamous intraepithelial lesions of vulvar with low incidence rate, but had more risk of progression. p53, p16 and Ki-67 stain were useful in the diagnosis of dVIN.关键词
外阴上皮内瘤变/分化型/p53/预后Key words
vulvar intraepithelial neoplasia/VIN/p53/prognosis分类
医药卫生引用本文复制引用
张和平,陈先侠,解正新,赵彩霞,汪勤,刘婷珽..6例分化型外阴上皮内瘤变临床病理观察[J].临床与实验病理学杂志,2015,(7):752-755,756,5.
