临床与实验病理学杂志Issue(7)：776-779,4.DOI:10.13315/j.cnki.cjcep.2015.07.014
结直肠筛状粉刺型腺癌的临床病理特征与预后的关系
Correlation of clinicopathological features and prognosis in patients with colorectal cribriform comedo-type adenocarcinoma
摘要
Abstract
Purpose To investigate the clinicopathological features and prognosis in patients with colorectal cribriform comedo-type ad-enocarcinoma. Methods Compared with 278 cases of colorectal common-type adenocarcinoma, 24 cases of colorectal cribriform come-do-type adenocarcinoma were analyzed for clinical stage, lymphovascular invasion, lymph node metastasis and genetic characteristics. Results The percentage of clinical Ⅲ and Ⅳ (87. 5%) and lymph node metastasis rate (87. 5%) in patients with colorectal cribri-form comedo-type adenocarcinoma was obviously higher than that in colorectal common-type adenocarcinoma (42. 4%,42. 4%) (P<0. 05). The percentage of lymphovascular invasion (87. 5%) of colorectal cribriform comedo-type adenocarcinoma were significantly higher than that of common-type adenocarcinoma (22. 7%) (P<0. 05). There were no statistical significance of age, sex, and molec-ular genetics of KRAS and mutated BRAF mutation between two groups ( P>0. 05 ) . Conclusions There is a higher clinical stage and poorer prognosis including unique morphological characteristics, highly lymphovascular invasion and lymph node metastasis in pa-tients with colorectal cribriform comedo-type adenocarcinoma.关键词
结直肿瘤/腺癌/筛状粉刺型/预后Key words
colorectal neoplasm/adenocarcinoma/cribriform comedo-type/metastasis分类
医药卫生引用本文复制引用
张丽华,陈小岩,王晨,陈顺华,曹立宇..结直肠筛状粉刺型腺癌的临床病理特征与预后的关系[J].临床与实验病理学杂志,2015,(7):776-779,4.基金项目
福建省卫生厅青年课题基金(2010.3054)、安徽省高等学校省级自然科学研究基金(KJ2013A150) （2010.3054）
