临床与实验病理学杂志Issue(7)：784-788,5.DOI:10.13315/j.cnki.cjcep.2015.07.016
肺原发性非霍奇金淋巴瘤28例临床病理分析
Clinicopathological analysis of primary non-Hodgkin lymphoma of lung---28 cases report
摘要
Abstract
Purpose To explore the clinicopathological characteristics of primary non-Hodgkin lymphoma ( PNHL) of lung. Methods The clinical features, morphology and immunohistopathological phenotypes were retrospectively studied in 28 cases of PNHL and re-viewed of the literature. Results The composition of this group of cases is 18 cases of male, 10 cases female. The a median age of pa-tients was 57 years old. According to the WHO classification, all of the 28 cases of in our PNHL series were diagnosed as non-Hodgkin lymphoma ( NHL) , including 17 mucosa-associated lymphoid tissue extranodal marginal zone lymphomas ( MALT) , 5 diffuse large B cell lymphomas ( DLBLC) , 2 NK/T cell lymphomas and 2 anaplastic large cell lymphomas, 1 mantle cell lymphoma ( MCL) and 1 pe-ripheral T cell lymphomas, unspecified, respectively. One-third PNHL patients presented with specific clinical symptoms such as cough, chest pain, dyspnea, and fatigue, Imaging examination showed unilateral or bilateral pulmonary infiltrate, single lesions or multiple nodules, and the lesions always involved with the trachea, bronchus and lung. Follow-up was completed in 16 patients ( range, 3 to 38 months) . 3 cases were conducted with pneumonectomy, among which 2 cases were given postoperative adjuvant chem-otherapy. Seven patients were given chemotherapy alone, and 5 patients did not give any treatment following initial diagnosis. At the time of last follow-up, 13 patients were alive with disease, 2 patients were died. The tumor metastasis in the left inguinal lymph node was found in one patient after 2 years by surgery. Conclusions It was shown that there was no specific clinical manifestations and fea-tures of pulmonary PNHL. Among of them, the MALT is the most common diseases, and the highly aggressive lymphomas many be oc-cur, such as the DLBLC, NK/T cell lymphoma. The diagnosis of PNHL depends on pathological examination. The immunohistochemi-cal staining and molecular pathological technology may helpful for the diagnosis and differential diagnosis of the tumors.关键词
肺肿瘤/淋巴瘤/黏膜相关淋巴组织淋巴瘤/诊断/预后Key words
lung neoplasm/lymphoma/mucosa-associated lymphoid tissue lymphoma/diagnosis/prognosis分类
医药卫生引用本文复制引用
张锦,黄幸,陆珍凤,周晓军,印洪林..肺原发性非霍奇金淋巴瘤28例临床病理分析[J].临床与实验病理学杂志,2015,(7):784-788,5.基金项目
中国博士后科学基金面上资助(201150M1575)、中国博士后科学基金特别资助(2012T50895) （201150M1575）
