闵颖 1边素艳 1叶平 1骆雷鸣 1肖文凯 1吴红梅1
作者信息
摘要
Abstract
Objective A cross-sectional was conducted to investigate the correlation of pulse wave velocity (PWV)and metabolic syndrome (MS)factors.Methods All the adult participants in this cross-sectional investi-gation were recruited from 3 big communities during their annual physical examination.Regional arterial stiffness was assessed simultaneously by measuring PWV in three arterial segments,carotid -femoral (cfPWV),carotid -radial (crPWV)and carotid-ankle PWV (caPWV).Demographic characteristics and basal biochemical parameters inclu-ding height,weight,waist and hip circumference,blood pressure,and serum levels of glucose,lipid,uric acid and cre-atinine were collected.MS was identified according to the criteria from the International Diabetes Federation defini-tion.Results A total of 2439 citizens (aged 18 to 92 years)were enrolled into this study,which included 732 partic-ipants with MS (prevalence,30.01%).The subjects with MS were older[(53.25 ±13.73)vs.(50.03 ±15.73), P<0.01],and had a higher cfPWV,caPWV,crPWV(11.68 ±2.92)m/s vs.(10.24 ±2.43)m/s,(9.46 ±1.73) m/s vs.(8.76 ±2.23)m/s,(9.76 ±1.52)m/s vs.(9.42 ±1.45)m/s,P<0.01 for all],and an increased inci-dence of cardiovascular diseases (18.3% vs.9.1%,P<0.001).Partial correlation analysis after adjustment for age and sex showed that pulse pressure,LDL-C,uric acid and all component of MS were significantly correlated to the values of cfPWV and caPWV (P<0.05 for all).The results of multivariate stepwise linear regression analysis indicated that MS was an independent risk factor for the cfPWV,cfPWV and caPWV.Further analysis showed that increased sys-tolicblood pressure and hyperglycemia were the independent risk factors for cfPWV and caPWV ,and the diastolic blood pressure for crPWV.Central obesity was correlated with enhanced cfPWV,while no correlation was observed be-tween the level of serum triglyceride,high density lipoprotein and PWV.Conclusion MS is the independent risk fac-tor for the arteriosclerosis,of which central obesity,hypertension and hyperglycemia are the major contributor to in-creased arteriosclerotic risk.关键词
代谢疾病/危险因素/脉搏/动脉硬化Key words
Metabolic diseases/Risk factors/Pulse/Arteriosclerosis分类
医药卫生
