中国临床保健杂志Issue(3)：288-290,3.DOI:10.3969/J.issn.1672-6790.2014.03.021
组织因子途径抑制物-2和趋化因子受体-4在非小细胞肺癌组织中的表达及临床意义
Clinical significance of TFPI-2 and CXCR4 expression in non-small cell lung cancer
摘要
Abstract
Objective To explore the expression of tissue factor way inhibitor-2 (TFPI-2 )and chemokine receptor-4 (CXCR4)protein,clinical pathological characteristics and prognosis in the non-small cell lung cancer (NSCLC).Methods The expression of TFPI-2 and CXCR4 in tumor issues and adjacent normal lung tissues collect-ed from 60 NSCLC patients,and normal tissue collected from 10 healthy subjects were detected by immunohistochem-istry.The correlation of the level of CXCR4 and TFPI-2 and the gender,age,histological type,degree of differentia-tion,lymph node metastasis,TNM stage was analyzed.Results The level of TFPI-2 in tumor tissues was significantly lower than that in carcinoma adjacent tissues and normal tissues,and the level of CXCR4 in the tumor tissue is obvi-ously higher than that in the carcinoma adjacent tissues and normal tissues (P<0.05 ).There was an correlation of TFPI-2 and CXCR4 level with lymph node metastasis (P<0.05 ),but this correlation was not seen in the gender, age,histological type,degree of differentiation and TNM staging.The TFPI-2level was negatively correlated with CX-CR4 level in NSCLC (r=0.26,P<0.05 ).Conclusions TFPI-2 may influence the migration of tumor metastasis through the inhibition of increased CXCR4 expression.关键词
癌,非小细胞肺/受体,CXCR4/丝氨酸蛋白酶抑制剂Key words
Carcinoma,non-small-cell lung/Receptors,CXCR4/Serine proteinase inhibitors分类
医药卫生引用本文复制引用
纪涛,朱水波,董永强,张晓明,梁江水,殷桂林..组织因子途径抑制物-2和趋化因子受体-4在非小细胞肺癌组织中的表达及临床意义[J].中国临床保健杂志,2014,(3):288-290,3.基金项目
武汉市青年科技晨光计划项目 （）
