中国临床保健杂志Issue(3)：291-293,3.DOI:10.3969/J.issn.1672-6790.2014.03.022
真武汤对单侧输尿管梗阻模型大鼠整合素连接激酶和血管紧张素Ⅱ的干预研究
Effect of Zhenwu decoction on integrin-linked kinase and angiotensin Ⅱ in UUO rats
周波 1宋立群 2贠捷 3张丹萍 4宋业旭 3马艳春 3陈方明1
作者信息
- 1. 四川达州市中西医结合医院肾内科，635002
- 2. 黑龙江中医药大学附属第一医院
- 3. 黑龙江省中医药大学
- 4. 四川省达州市畜禽繁育改良站
- 折叠
摘要
Abstract
Objective To research the effect of Zhenwu decoction on the expression of integrin linked kinase and angiotensin II,l and the renal interstitial fibrosis in UUO rats.Methods The rat model of renal interstitial fibro-sis was successfully established by unilateral ureteral obstruction(UUO).The rats were divided into the control group and the model group,and the Zhenwu decoction group (low dose,middle dose,high dose)and Niao Du Qing granules control group.The corresponding drug were administrated,and the urine and serum were collected after 2,3and 4 weeks.The level of 24 hours urinary protein were tested by biochemical testing and the expression of integrin-linked kinase and angiotensionⅡwere determined by ELASA.Results Zhenwu decoction could significantly reduce the ex-pression of ILK and Ang-II in UUO rat model,and the lowest level of ILK and Ang- II were observed in the middle dose group.Conclusion Zhenwu decoction can inhibite the expression of Ang-Ⅱ and ILK in the UUO rats model, and slow the progress of renal interstitial fibrosis.关键词
输尿管梗阻/医学,中国传统/纤维化/血管紧张素Ⅱ/丝氨酸蛋白酶类/大鼠,WistarKey words
Ureteral obstruction/Medicine,Chinese traditional/Fibrosis/Angiotensin II/Serine proteases/Rats,Wistar分类
医药卫生引用本文复制引用
周波,宋立群,贠捷,张丹萍,宋业旭,马艳春,陈方明..真武汤对单侧输尿管梗阻模型大鼠整合素连接激酶和血管紧张素Ⅱ的干预研究[J].中国临床保健杂志,2014,(3):291-293,3.
