中国临床保健杂志Issue(5)：489-492,4.DOI:10.3969/J.issn.1672-6790.2014.05.015
高血压患者血管内皮功能及颈动脉内膜中层厚度与室间隔厚度的关系
The correlation between vascular endothelial function and carotid intima-media thickness and ventricu-lar septal thickness in patients with hypertension
摘要
Abstract
Objective To investigate the relationship and clinical significance between vascular endothe-lial function and carotid intima-media thickness(IMT)in hypertensive patients with ventricular septal hypertro-phy.Methods Eighty-five hypertensive patients were slected.The carotid intima-media thickness,brachial ar-tery vascular endothelial function and the ventricular septal were detected by ultrasonography.The hypertensive patients were divided into normal septal group and hypertrophy septal group according to the ventricular septal thickness,meanwhile nitric oxide (NO )、endothelin (ET-1 )、fasting blood-glucose (FBG),total cholesterol (TC)、low-density lipoprotein cholesterol(LDL-C)were measured.Thirty healthy subjects were selected as con-trol group.Results Compared with the control group and normal septal group,endothelium-dependent vasodila-tation function and nitric oxide(NO)concentration was significantly lower in septal hypertrophy group,moreover, the septal hypertrophy group showed a significant increase of intima-media thickness(IMT)and ET-1 (P <0. 05 );pearson correlation analysis indicated that ventricular septal thickness was positively correlated with IMT(r=0.533)and ET-1 (r =0.673 ),negatively correlated with FMD (-0.628 )and NO(r =-0.629 );What's more,a negative correlation was showed between IMT and FMD(r =-0.706 ).Conclusion Hypertensive pa-tients have endothelial dysfunction,especially vascular endothelial function and carotid artery.关键词
高血压/内皮,血管/颈动脉内膜中膜厚度/室间隔Key words
Hypertension/Endothelium,vascular/Carotid intima-media thickness/Ventricular septum分类
医药卫生引用本文复制引用
江洁,王邦宁,郑慧,帅秀芳..高血压患者血管内皮功能及颈动脉内膜中层厚度与室间隔厚度的关系[J].中国临床保健杂志,2014,(5):489-492,4.基金项目
安徽省自然科学基金项目资助 （）
