摘要
Abstract
Objective To investigate the effects of electroacupuncture at "Sanyinjiao"on estrogen and monoamine neurotransmittersof natural menopausal rats.Methods Rats were divided into normal group,model group and electroacupuncture group randomly.Electro acupuncture group rats were acupunctured in Sanyinjiao for 1 5 therapies,each therapy was given once every other day.The rats inother two groups were fed as the model groupbut without acupuncture.ELISA method was applied to detect the levels of ovarian estradiol (E2)and monoamine neuro-transmitters in hippocampus.Results Compared with the normal group,the concentrationof ovarianE2 in model grouprats decreased by 59.1 7% (P <0.01 ).After the treatment of theelectro -acupuncture,the level of E2 was sig-nificantly increased by 65.49% (P <0.01 )compared with the model group,but the level was not restored to the nor-mal level (P <0.01 ).The central neurotransmitter results showthat compared with the normal group,the content of 5-HT in hippocampus in the model group rats increased by 34.35%.The levels of NE,DA were decreased by 33. 86% and 34.38% respectively (P <0.01 )in model group rats.The content of 5-HT in the treatment group rats were decreased by 1 1 .1 3% (P <0.05)compared with the model grouprats.However,NE was significantly up-regulated by1 9.1 8% (P <0.05)at the same time.DA intreatment group rats was increased by 7.59%,but had no statistical significance with the model group (P >0.05).Compared with the normal group,the ratio of 5-HT/NE in model group ratsincreased significantly (P <0.01 ).After the treatment of the electro-acupuncture,the ratio 5-HT/NE of the treatment group decreased significantly by23.47% (P <0.01 ).Conclusion Electroacupuncture at "Sanyinjiao"point can regulate sex hormone levels and monoamine neurotransmitter levels in the natural climacteric rats.关键词
围绝经期/电针/穴,三阴交,血清素/雌二醇/大鼠,Sprague -DawleyKey words
Perimenopause/Electroacupuncture/Point SP6/Serotonin/Estradiol/Rats,Sprague-Dawley分类
医药卫生
