中国临床保健杂志Issue(2)：182-184,3.DOI:10.3969/J.issn.1672-6790.2015.02.023
坎地沙坦对自发性高血压大鼠骨骼肌核转录因子-2表达和胰岛素敏感性的影响
Effects of candesartan on the expression of Nrf2 and insulin sensitivity in the spontaneous hypertension rats
摘要
Abstract
Objective To investigate the effects of candesartan on the expression of Nrf2 and insulin sensi-tivity of the spontaneously hypertensive rats(SHR)and its possible mechanism.Methods 30 SHR were randomly di-vided into model group,low dose group and high dose group.10 WKY rats served as control group.All the rats fed with fructose,while the low and high dose group rats accepted candesartan consecutive treatment with the dose of 0.4 mg/kg and 0.8 mg/kg respectively.At the 8th weekend,the insulin resistance index(HOMA-IR),the level of reactive oxygen species(ROS)and the expression of Nrf2 were detected.Results Compared with the control group,the HO-MA-IR was significantly increased in the model group(P <0.05),the protein expression of Nrf2 in model group sig-nificantly decreased(P <0.01)at the same time while the level of ROS increased significantly(P <0.01).Compared with the model group,the HOMA-IR decreased obviously in the high dose group (P <0.01).The protein expression of Nrf2 in the low dose and high dose group increased significantly (P <0.01,P <0.05)compared with model group,and the level of ROS significantly decreased compared with the model group(P <0.05).Conclusion Candesartan could improve the insulin resistance and oxidative stress by the antagnism effect of AngⅡin the skeletal muscle cells.关键词
高血压/血管紧张素Ⅱ/胰岛素抗体/活性氧/大鼠,近交SHRKey words
Hypertension/AngiotensinⅡ/Insulin antibodies/Reactive oxygen species/Rats,Inbred SHR分类
医药卫生引用本文复制引用
李凡,谢静,郝华,黄慧,曾强..坎地沙坦对自发性高血压大鼠骨骼肌核转录因子-2表达和胰岛素敏感性的影响[J].中国临床保健杂志,2015,(2):182-184,3.基金项目
北京市自然科学基金项目 （）
