刘永菊 1李素梅 1荆春艳 1王菊梅 1姜妍芳 1孙科1
作者信息
- 1. 安徽医科大学附属安徽省立医院 安徽省立医院内分泌科，合肥 230001
- 折叠
摘要
Abstract
Objective To assess the correlation between the changes of bone mineral density and serum par-athyroid hormone(PTH),25-hydroxyvitamin D[25(OH)D3],N-terminal-midfragment of osteocalcin (N-MID-OT), total N-terminal propeptide of type I procollagen (T-P1NP)and β-collagen specific sequences (β-CTX)in postm-enopasual women with type 2 diabetes mellitus.Methods 81 postmenopausal women with type 2 diabetes mellitus were recruited and divided into three groups according to the level of bone mineral density,including the control group (n =35),the osteopenia group(n =31)and osteoporosis group(n =15),The height and weight were measured,the level of fasting plasma glucose (FPG),serum lipid,total glycated hemoglobin(HbA1 c),calcium,phosphorus,magne-sium,alkaline phosphatase (ALP),PTH,25 (OH)D3,N-MID-OT,T-P1NP and β-CTX,and the weight mass index (BMI)was calculated.Results There were no significantly differences in FPG,calcium,phosphorus,ALP,serum lipid,PTH levels among the three groups.The levels of Body Mass Index(BMI)and HbA1c in osteoporosis group were lower than those in osteopenia group and control group(P <0.05).The levels of serum 25(OH)D3,N-MID and T-P1NP in groups of osteoporosis and osteopenia were lower than those in control group,while the level of serum β-CTX was on the contrary.The Pearson correlation analysis showed that bone mineral density were significantly positively correlated with the level of BMI ,25(OH)D3,N-MID and T-P1NP ,while the opposite trends were found with the lev-el of age and serum β-CTX .Conclusions The osteoporosis or osteopenia are most likely occur in postmenopasual women with type 2 diabetes mellitus and the changes of bone mineral density is closely correlated with to bone turn-over marker,25(OH)D3,age and the level of blood glucose.关键词
糖尿病,2 型/骨密度/骨质疏松,绝经后/甲状旁腺素/骨化二醇Key words
Diabetes Mellitus,Type 2/Bone density/Osteoporosis,postmenopausal/Parathyroid hormone/Calcifediol分类
医药卫生
