皮肤性病诊疗学杂志Issue(5)：367-371,5.DOI:10.3969/j.issn.1674-8468.2014.05.004
结节性痒疹患者皮损中蛋白酶活化受体2的表达与分布
The Expression and Tissue Distribution of Protease Activated Receptor-2 in Prurigo Nodu-laris
李仰琪 1陆春 2田歆 1马少吟1
作者信息
- 1. 广州市皮肤病防治所皮肤科，广东 广州 510095
- 2. 中山大学附属第三医院皮肤科，广东 广州510630
- 折叠
摘要
Abstract
Objective:To investigate the expression and tissue distribution of protease activated receptor-2(PAR-2) in patients with lesions of prurigo nodularis (PN),and to study the role of PAR-2 in the development of pruritus in PN .Methods:Skin tissue samples were collected from 20 healthy controls and 22 patients with PN .Immunohistochemical SP staining was carried out to de-tect the expression level and distribution of PAR-2 in skin tissues of patients with lesions group , non-lesional group and normal control group .The expression level in three groups were compared with each other .Visual analogue scale was used to calculate the subjective degree of itching of 22 patients with PN , and the correlation between visual analogue scale and PAR-2 expression level were analyzed .Results:Normal skin tissues , lesions and non-lesional skin tissues of prurigo nodu-laris were positively stained by PAR-2.The cytoplasm and membrane of keratinocytes in epidermal acanthosis and basal layer were the mainly expressing sites .The expression level of PAR-2 was significantly higher in patients with lesions group than in the healthy controls and the non -lesional group of PN (t=2.34, 2.10, P<0.05).Subjective degree of itching of 22 patients with PN u-sing visual analogue scale was correlated positively with the expression level of PAR -2 in lesion of patients of PN ( r =0.62, P <0.05 ) .Conclusion:PAR-2 was closely related with the pruritus pathogenesis in PN .关键词
结节性痒疹/免疫组织化学/蛋白酶活化受体-2/瘙痒Key words
Prurigo nodularis/Immunohistochemical staining/Protease activated receptor-2/Pruritus分类
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李仰琪,陆春,田歆,马少吟..结节性痒疹患者皮损中蛋白酶活化受体2的表达与分布[J].皮肤性病诊疗学杂志,2014,(5):367-371,5.
