皮肤性病诊疗学杂志Issue(3)：175-178,4.DOI:10.3969/j.issn.1674-8468.2015.03.006
血清（1-3）-β-D-葡聚糖检测对深部真菌感染辅助诊断的临床价值
Clinical Evaluation of (1, 3)-β-D-glucan in the Diagnosis of Invasive Fungal Infection
摘要
Abstract
Objective:To evaluate the clinical value of(1, 3)-β-D-glucan (BDG) on the diag-nosis of invasive fungal infection.Methods:The suspected invasive fungal infection patients from Sun Yet-sen memorial hospital were enrolled in this study.The blood samples were taken from each patient and tested by determination of (1, 3)-β-D-glucan and culture.The sensitivity, spe-cificity, positive predictive value and negative predictive value were compared between these two methods.Results:171 patients were identified as positive by the detection of plasma BDG, with the positive rate of 50.89%( 171/336 ) .141 samples were identified as positive by fungal cul-tures, with the positive rate of 41.96%(141/336) .The concentration of plasma BDG in the inva-sive fungal infection group with positive fungal culture was (131.18 ±102.91) pg/mL, w hile the concentration of plasma BDG in invasive fungal infection group with negative fungal culture was (45.06 ±33.64 ) pg/mL.There were statistically significant differences in the concentration of plasma BDG between the two groups(t=9.57, P<0.01).Based on the results of the fungal cul-tures, the sensitivity, specificity, and positive and negative predictive values for BG were 54.61%(77/141), 51.79%(101/195), 45.03%(71/171) and 61.21%(101/165), respectively.The genus of Candida is still the predominant pathogens of invasive fungal infection.Conclusions:The determination of plasma (1, 3)-β-D-glucan could be used as an fast tool for invasive fungal infec-tion diagnosis, but the results need to be confirmed by culture.The combination of both methods could be used for routine diagnosis of invasive fungal infection in clinic.关键词
深部真菌感染/(1-3)-β-D-葡聚糖/真菌培养/诊断Key words
Invasivefungalinfection/(1,3)-β-D-glucan/Fungalculture/Diagnosis分类
医药卫生引用本文复制引用
蔡文莹,鲁长明,席丽艳..血清（1-3）-β-D-葡聚糖检测对深部真菌感染辅助诊断的临床价值[J].皮肤性病诊疗学杂志,2015,(3):175-178,4.基金项目
“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项 （）
