不同疗程长脉宽 Nd∶YAG 1064 nm 激光治疗甲真菌病的疗效观察OA

Objective:To evaluate the efficacy and safety of different courses of long pulsed Nd∶YAG 1 064 nm laser in the treatment of onychomycosis.Methods:Forty-Three patients with onychomycosis randomly divided into 2 groups were treated by long pulsed Nd∶YAG laser.Pa-tients of group A received treatment once a week for 4 weeks, and patients of group B received treatment for up to 8 weeks.Clinical and mycological efficacy were evaluated 16 weeks and 24 weeks after the beginning of treatment.Side effects were recorded and analyzed.Data were pro-cessed using SPSS 17.0 software.Chi-square test was performed to compare the clinical and myco-logical efficacy between two groups.Results:A total of 138 nails of 43 patients were treated in this study.There were 70 nails of 24 cases in group A and 68 nails of 19 cases in group B.At 16 weeks and 24 weeks, no statistical difference was observed in the mycological efficacy between two groups (P>0.05).At 12 weeks, clinical response rates in group A, B were 58.6%, 75.0%, respectively.There was significant difference in the clinical efficacy between the two groups (χ²=4.19,P<0.05).At 24 weeks, clinical response rates in group A, B were 42.9%,58.8%,re-spectively.There was no significant difference between the two groups (χ²=3.52,P>0.05). There was no obvious adverse reaction but pain during the treatment.Conclusion:Long pulsed Nd∶YAG 1 064 nm laser appears for be an effective and safe approach for the treatment of mild on-ychomycosis, and prolonging the course of therapy can increase the short-term (12 weeks) treat-ment outcomes.