泸州医学院学报Issue(2)：124-126,3.DOI:10.3969/j.issn.1000-2669.2015.02.003
芪柴煎剂对变应性鼻炎大鼠血清IL-4,IFN-γ影响的实验研究
Effect of Qi Chai decoction on serum IL-4, IFN-γlevel in allergic rhinitis rats
胥彪 1胡文健2
作者信息
- 1. 达州市中西医结合医院耳鼻咽喉头颈外科，四川达州 635000
- 2. 泸州医学院附属中医医院耳鼻咽喉科，四川泸州 646000
- 折叠
摘要
Abstract
Objective: To study the influence of Qi Chai decoction on serum IL-4, IFN-γ level of allergic rhinitis model of rats so as to explore its role and efficacy in treating allergic rhinitis. Methods:Rats with allergic rhinitis were made by ovalbumin as sensitizing agent. 40 healthy adult SD rats were randomly divided into five groups(8 rats each):normal control group low-dose and high dose Qi Chai decoction groups,loratadine group, and model control group. Corresponding mjodel control given for 14 consecutive days in each group. Then the serum IL-4 and IFN-γ contents were tested by ELISA. Results: Compared with model control group,the serum IL-4 levels of low dose and high dose Qi Chai decoction groups and desloratadine group were significantly lower, and there were significant differences (P<0.05), and IL-4 level of low dose Qi Chai decoction group was higher than that of high dose group (P< 0.05). Compared with model control group, the serum IFN-γ level of low dose and high dose Qi Chai decoction groups, and the desloratadine group were significantly higher (P< 0.05). Compared with high dose group, the serum IFN-γ level of low dose Qi Chai decoction group and loratadine group were significantly lower (P< 0.05). Conclusion: The Qi Chai decoction can down-regulate the serum IL-4 levels and up-regulate the serum IFN-γlevels of the rats with allergic rhinitis.关键词
IL-4/IFN-γ/变应性鼻炎大鼠模型/芪柴煎剂Key words
IL-4/IFN-γAllergic rhinitis rat model/Qi Chai decoction分类
医药卫生引用本文复制引用
胥彪,胡文健..芪柴煎剂对变应性鼻炎大鼠血清IL-4,IFN-γ影响的实验研究[J].泸州医学院学报,2015,(2):124-126,3.
