摘要
Abstract
Objective: To investigate the diagnostic value of serum pepsinogen I (PGI), PGI/II ratio, carcinoembryonic antigen (CEA) and combined detection of the three indexes in gastric cancer. Methods 171 patients with gastric diseases were divided into gastric cancer group of 68 cases and gastritis group of 103 cases, with 50 healthy people as control group. Serum PGI, PGII and CEA were detected by turbidimetric immunoassay and chemiluminescence method, respectively, and PGI/II ratio was calculated. Receiver operator characteristic(ROC) curve was set up, and sensitivity, specificity, positive and negative predictive value for PGI, PGI/II ratio, CEA and combined detection of the three indexes were analyzed. ResultsSerum PGI, PGII levels, PGI/PGII ratio and combined detection of the three in gastric cancer group were significantly lower than those in gastritis and healthy controls group(P<0.01, P<0.05), Serum PGI levels in gastritis group was significantly lower than those in healthy control group (P < 0.05), serum CEA levels in gastric cancer group were significantly higher than those in gastritis and healthy control group (P< 0.01 ).When PGI ≤ 50 μg/L, PGI/II ratio ≤ 2.5 and CEA ≥10.0μg/L, the sensitivity of serum PGI, PGI/II ratio and CEA for diagnosis of gastric cancer were 58.8%, 23.5%, 23.5% and 58.8%, the specificity were 88.5%, 88.5%, 100% and 76.9%, the positive predictive were 76.9%, 57.1%, 100% and 62.5%, the negative predictive were 76.7%, 63.9%, 66.7% and 74.1%, respectively. The area under ROC curve for serum PGI、PGI/II and CEA were 0.974, 0.732 and 0.491, respectively. Conclusion: Serum PGI, PGI/II ratio shows a low sensitivity and specificity for the diagnosis of gastric cancer. However, combined detection of PGI, PGI/II ratio and CEA may help the differential diagnosis of gastric cancer from gastritis.关键词
胃蛋白酶原/癌胚抗原/胃癌Key words
Pepsinogen/Carcinoembryonic antigen/Gastric cancer分类
医药卫生
