国际眼科杂志Issue(7)：1253-1256,4.DOI:10.3980/j.issn.1672-5123.2014.07.21
玻璃体腔内注射雷珠单抗联合黄斑格栅样光凝治疗糖尿病黄斑水肿
Efficacy of intravitreal ranibizumab injection combined with macular grid photocoagulation for diabetic macular edema
摘要
Abstract
AlM:To evaluate the clinical efficacy of intravitreal injection of ranibizumab combined with macular grid photocoagulation for diabetic macular edema ( DME) .METHODS:Totally 60 eyes ( 60 patients ) with DME were randomly divided into 2 groups: 30 eyes of simple injection group underwent intravitreal injection of ranibizumab, and 30 eyes of combined treatment group underwent intravitreal injection of ranibizumab and macular grid photocoagulation 1wk later. The best corrected visual acuity ( BCVA ) , central macular thickness ( CMT ) measured by optical coherence tomography ( OCT ) and postoperative complications were observed. <br> RESULTS:ln simple injection group, the BCVA after operation were separately 0. 390 ± 0. 075 (4wk), 0. 367 ± 0. 088 (8wk) and 0. 319 ± 0. 064 (12wk), the CMT after operation were separately 221. 63 ± 112. 34μm (4wk), 337. 73±99. 56μm (8wk) and 432. 92 ± 100. 46μm (12wk), which were much better than pre-operation. But during follow-up, the BCVA presented down trend and the CMT was on the rise slowly. ln combined treatment group, the BCVA after operation were separately 0. 385 ± 0. 036 (4wk), 0.382±0.079 (8wk) and 0.377±0.097 (12wk),the CMT after operation were separately 249. 77 ± 106. 55μm (4wk), 270. 40 ± 92. 88μm (8wk) and 275. 84 ± 97. 34μm (12wk ), which were satisfactory and steady during follow-up, better than simple injection group (P<0. 05).CONCLUSlON:lntravitreal injection of ranibizumab can effectively improve visual acuity and decrease central foveal thickness for patients with DME, combining with macular grid photocoagulation can ensure therapeutic effects steady and permanent.关键词
雷珠单抗/格栅样光凝/糖尿病黄斑水肿Key words
ranibizumab/grid photocoagulation/diabetic macular edema引用本文复制引用
姜虎林,韩旭巍,张生奇,房修岭,赵博军..玻璃体腔内注射雷珠单抗联合黄斑格栅样光凝治疗糖尿病黄斑水肿[J].国际眼科杂志,2014,(7):1253-1256,4.基金项目
山东省自然科学基金(No. ZR2010HM098) （No. ZR2010HM098）
山东省科技发展计划项目(No.2010G0020256) （No.2010G0020256）
