国际眼科杂志Issue(11)：1943-1945,3.DOI:10.3980/j.issn.1672-5123.2014.11.07
双丹明目胶囊对糖尿病视网膜病变大鼠血糖及视网膜功能的影响
Effects of Shuangdanmingmu capsule on blood glucose and retinopathy in rats with diabetic retinopathy
摘要
Abstract
AIM: To observe pathological changes of blood glucose, the retina and pancreatic tissue after establishing rats diabetic retinopathy ( DR) model, and preliminary evaluate of Shuangdanmingmu capsule on the improvement of retina and pancreas tissue structure.METHODS: DR rats were fed with Shuangdanmingmu capsule. Then the blood glucose and glycated hemoglobin were determined. Immunohitochemical staining was used to observe the expression of structure of retino and pancreas. <br> RESULTS:Compared with the control group, the blood glucose and glycates hemoglobin in Shuangdanmingmu group were decreased after 2mo of treatment (P<0. 01). The layers tissue of retina was less edema and gradually arranged in Shuangdanmingmu group. The structure of pancreas was clear basically. Fat cells, infiltrati on of lymphocytes and fibrosis hyperplasia appeared in the interacinar and interlobular connective tissue. Some acinar and islet cells of fatty rat pancreatic tissue had fatty or vesicular degeneration. <br> CONCLUSION: Shuangdanmingmu capsule can decrease blood glucose and glycates hemoglobin in DR rats effectively and improve the ultrastructure of retina and pancreas tissue.关键词
糖尿病视网膜病变/双丹明目胶囊/血糖/视网膜/胰腺Key words
diabetic retinopathy/Shuangdanmingmu capsule/blood glucose/retina/pancreas引用本文复制引用
秦裕辉,李文娟,张熙,戴宗顺,陈晓柳,周亚莎,凌艳君,郑兵..双丹明目胶囊对糖尿病视网膜病变大鼠血糖及视网膜功能的影响[J].国际眼科杂志,2014,(11):1943-1945,3.基金项目
国家自然科学基金面上项目( No.81473737) （ No.81473737）
湖南省教育厅科研基金重点项目(No.13A072) @@@@ National Natural Science Foundation of China (No.81473737) （No.13A072）
Key Project Foundation of Educational Research of Hunan Educational Committee (No.13A072) （No.13A072）
