国际眼科杂志Issue(11)：1950-1952,3.DOI:10.3980/j.issn.1672-5123.2014.11.09
形觉剥夺性近视豚鼠视网膜形态学观察及TGF-β2表达
Structure changes of retina and expression of TGF-β2 in the retina in form deprivation myopia of guinea pigs
周凌霄 1王理论 2张林3
作者信息
- 1. 710077 中国陕西省西安市，西安医学院第一附属医院眼科
- 2. 716000 中国陕西省延安市，延安大学附属医院眼科
- 3. 710061 中国陕西省西安市，西安交通大学第一附属医院眼科
- 折叠
摘要
Abstract
AIM: To observe the structure changes of retina and determine the expression of TGF-β2 in retina model. At the same time to clarify the function of TGF-β2 in form deprivation myopia model.
<br> METHODS: A facemask was worn on the right eyes of guinea pigs to develop form deprivation myopia. Before and after experiment, refraction was measured using retinoscope, and ocular axial was determined by A-scan ultrasonography. Morphologic alternations of the retina were observed by light microsope. The expression of TGF - β2 in the retina was determined by immunohistochemistry.
<br> RESULTS:Retina of myopic eyes became thinner, and inner nuclear layer of retina had few layers, nuclear of outer nuclear layer became smaller and circular, at the same time, they arranged in disorder. The immunohistochemisty results showed that expression of TGF-β2 in model eyes was lower than that in control eyes (P<0. 05).
<br> CONCLUSION: Covering eyes with facemasks is effective, simple and convenient in making myopic model. The retina of the model eye appeares degeneration. TGF-β2 plays an important role in the course of development in form deprivation myopia.关键词
形觉剥夺性近视/视网膜/TGF-β2Key words
form deprivation myopia/retina/TGF-β2引用本文复制引用
周凌霄,王理论,张林..形觉剥夺性近视豚鼠视网膜形态学观察及TGF-β2表达[J].国际眼科杂志,2014,(11):1950-1952,3.
