国际眼科杂志Issue(1)：30-33,4.DOI:10.3980/j.issn.1672-5123.2015.1.07
双丹明目胶囊对 DR大鼠视网膜血管形态学及 VEGF表达的影响
Effects of Shuangdanmingmu capsule on retinal vascular morphology and VEGF expression in rats with diabetic retinopathy
摘要
Abstract
Abstract•AlM: To observe the effects of Shuangdanmingmu capsule on VEGF expression and retinal vascular morphology in rats with diabetic retinopathy ( DR) .•METHODS: DR rats were fed with Shuangdanmingmu capsule. By comparing with the normal group, the model control group, and positive control group, the effect of Shuangdanmingmu capsule on retinal tissue of DR rats was observed under electron microscopy. After HE staining, retinal structure was observed under the light microscope. lmmunohitochemical staining was used to detect the VEGF expression in retina.•RESULTS:Two months after treatment, the layers tissue of retina presented mild edema, capillary pericytes performed edema, mitochondria showed mild swelling and less clear structure, some endothelial cells showed slight proliferation in Shuangdanmingmu group. Compared with the normal group, the expression level of VEGF in retina increased in the other groups, especially in model control group. A significant differential in expression of VEGF was found between Shuangdanmingmu group, positive control group and model control group (P<0. 01).• CONCLUSlON: Shuangdanmingmu capsule can effectively improve the retinal microvascular, reduce edema and necrosis of each layer of retina, improve the ultrastructure of retina's tissue and inhibit VEGF expression in DR rats.关键词
糖尿病视网膜病变/双丹明目胶囊/视网膜/VEGFKey words
•KEYWORDS:diabetic retinopathy/Shuangdanmingmu capsule/retina/VEGF引用本文复制引用
秦裕辉,李文娟,张熙,戴宗顺,陈晓柳,周亚莎,凌艳君,郑兵..双丹明目胶囊对 DR大鼠视网膜血管形态学及 VEGF表达的影响[J].国际眼科杂志,2015,(1):30-33,4.基金项目
国家自然科学基金项目(No.81473737) （No.81473737）
湖南省教育厅科研基金重点项目(No.13A072)@@@@National Natural Science Foundation of China ( No.81473737) （No.13A072）
Key Project Research Foundation of Hunan Educational Committee (No.13A072) （No.13A072）
