摘要
Abstract
· AlM: To detect the effects of topical antiglaucoma medication on the ocular surface structures in glaucoma patients.
<br> · METHODS: Forty-nine eyes from 35 patients treated with topical antiglaucoma medication over 3mo and 45 eyes from 45 normal subjects were collected. The antiglaucoma medication group was divided to subgroup A ( single antiglaucoma medication treated group ) and subgroup B ( combined antiglaucoma medication treated group) .The ocular surface structures were performed in all subjects, including Schirmer l test ( S l t ) , tear film break-up time ( BUT ) , fluorescein staining ( FL ) , rose bengal staining ( RB ) , conjunctival impression cytology ( ClC ) , goblet cells density ( GCD ) , content of tear MUC5AC.
<br> ·RESULTS:The results of S l t was 11.54 ±5.47mm, and BUT was 11.86±3.13s, and FL and RB score was0.42±0.61 and 0.37±0.98 in normal control group, which was 8.11± 4.30mm and 7.49 ±2.62s, and 1.15 ±0.87, 1.28 ±1.08 respectively in antiglaucoma medication group. The differences were significant between normal group and antiglaucoma medication group ( t=3.395, P=0.001; t=7.363, P=0.001, t=-4.266, P=0.001;t=7.363, P=0.000);The results of S l t was 9.51 ±4.76mm, BUT was 8.46 ± 1.24s, and FL and RB score was 0.91±1.03 and 0.85±1.07 in subgroup A, which was 6.34±4.05mm and 6.38±1.25s, and FL and RB score was 1.84 ±1.14 and 1.56 ±1.31 in subgroup B. The differences were significant between subgroup A and subgroup B (t=2.514, P=0.012;t=5.844, P=0.000; t=-2.992, P=0.003; t=-2.072, P=0.043). Compared with normal control group, conjunctival epithelium cells damage was observed in antiglaucoma medication group that cell volume enlarged, and cytoplasm/nucleus decreased. The score of ClC of antiglaucoma medication group was significantly increased compared with normal control group (u=6.354, P =0.000 ) , while there was no difference between subgroup A and subgroup B (u=0.69, P=0.48).GCD of normal group and antiglaucoma medication group was (68.37 ±12.82 )/mm2 and ( 32.83 ±10.68 )/mm2 respectively.The difference was dramatically ( t=14.610, P=0.000 ); GCD of subgroup A and subgroup B was (39.12±9.35)/mm2 and (27.58±8.47)/mm2, which was statistically different (t=4.530, P=0.001).The content of tear MUC5AC was significantly decreased in antiglaucoma medication group (13.84 ±6.72ng/mL) compared with normal control group (32.61±8.65ng/mL) (t=11.804, P=0.000 ), while the content of tear MUC5AC was also significantly decreased in subgroup B (10.67±4.58ng/mL) compared with subgroup A ( 20.17 ±5.84ng/mL ) ( t =6.349, P=0.000) .
<br> · CONCLUSlON: Topical antiglaucoma medication can decrease tear secretionand tear film stability and damage ocular surface. Combined antiglaucoma medication caused severe damage on ocular surface structures.关键词
青光眼/青光眼药物/眼表结构Key words
glaucoma/glaucoma medication/ocular surface structures
