国际眼科杂志Issue(7)：1143-1147,5.DOI:10.3980/j.issn.1672-5123.2015.7.06
α-倒捻子素对小鼠视网膜光损伤的保护作用
Protective effect ofα-mangostin on retinal light damage in mice
摘要
Abstract
AlM:To discuss the protective effect ofα-mangostin on retinal light damage in mice.METHODS:Totally 30 Balb/c mice, aged 6~8wk, were randomly divided into the control group, light-exposure group and α-mangostin group. Every group contained 10 mice. Mice of α-mangostin group were treated with alpha-mangostin at the dose of 30mg/( kg · d ) body weight by intragastric administration daily for 7d, and then exposed to white light at the 5th d. The light-exposure group and α-mangostin group were exposed to 5 000 ± 200lx white light-emmiting diodes (LEDs) for continuously 1h to establish the mice model of retinal light damage. Flash -electroretinograme was recorded 72h after light exposure. The changes in retinal morphology of mice were observed by light microscopy. Retinas were extracted to detect the malondialdhyde ( MDA ) content change of the retinal homogenate.RESULTS: Flash-electroretinogram ( F-ERG ) showed that retinal dysfunction was less severe in α-mangostin group than in light-exposure group ( P<0. 05 ). Light microscopy test showed that retina structural damage was less severe in α-mangostin group than in light-exposure group (P<0. 05). The level of MDA in retinal tissue of α-mangostin group was significantly lower when compared with light-exposure group (P<0. 05).CONCLUSlON: α-mangostin inhibits lipid peroxidation induced by light damage and protect retina against light damage.关键词
视网膜光损伤/α-倒捻子素/氧化应激/视网膜电图/外核层/丙二醛Key words
retinal light damage/α - mangostin/oxidative stress/electroretinogram/outer nuclear layer/malondialdhyde引用本文复制引用
方圆,苏途,谢平,袁松涛,范雯,许译丹,胡仔仲,刘庆淮..α-倒捻子素对小鼠视网膜光损伤的保护作用[J].国际眼科杂志,2015,(7):1143-1147,5.基金项目
国家重点基础研究发展计划( No.2013CB967500,2011CB510200) （ No.2013CB967500,2011CB510200）
国家自然科学基金项目面上项目( No.81170855) （ No.81170855）
江苏省临床医学科技专项---重点病种的规范化诊疗研究( No. BL2014089) （ No. BL2014089）
江苏省“六大人才高峰”资助项目(No.2013-wsw-015)@@@@National Basic Research Program of China (973 Program, No.2013CB967500 and No.2011CB510200) （No.2013-wsw-015）
General Project of the National Natural Science Fund ( No.81170855) （ No.81170855）
Jiangsu Provincial Special Program of Medical Science ( No. BL2014089) （ No. BL2014089）
“Six Talent Peaks Project” in Jiangsu Province( No.2013-wsw-015) （ No.2013-wsw-015）
