中南医学科学杂志Issue(4)：331-335,342,6.
脉冲电磁场联合电针疗法对去卵巢大鼠骨质疏松的影响
Effects of Combination Treatment with Pulsed Electromagnetic Fields and Electroacupuncture on Ovariectomy-induced Osteoporosis in Rats
摘要
Abstract
Objective To explore whether combination treatment with pulsed electromagnetic fields ( PEMFs) and electroacupuncture ( EA) have additive benefits on bone mineral density( BMD) and biomechanical properties in OVX rats. Methods Fifty 3-month old female Sprague-Dawley rats were assigned to one of five groups:sham-operated control ( Sham) ,ovariectomy ( OVX) ,ovariectomy with PEMFs treatment ( PEMFs) ,ovariectomy with EA treatment ( EA) ,and o-variectomy with PEMFs﹢EA treatment ( PEMFs﹢EA) . After 12-week treatments,bone mineral density,histomorphometric parameters,and bone biomechanical properties were examined. Results PEMFs,EA and combination treatment signifi-cantly increased BMD of the femur (P<0. 01,P<0. 05) compared to OVX group. There was no significant difference in the femur BMD among the five groups(P>0. 05). PEMFs,EA and combination treatment significantly increased BMD of L5 vertebral body (P<0. 01) compared to OVX group. What’s more,combination treatment with PEMFs and EA was more ef-fective than PEMFs or EA alone for improving BMD in L5 vertebral body(P<0. 05). The biomechanical three-point ben-ding experiment showed that PEMFs and combination treatment significantly increased maximum load in the left femur com-pared to OVX group (P<0. 05). There was no significant difference in maximum load of the left femur among the five groups(P>0. 05). The compression test showed that PEMFs,EA and combination treatment significantly increased maxi-mum load (P<0. 01) and energy to failure (P<0. 01) in L5 vertebral body compared to OVX group. What’s more,combi-nation treatment was more effective than PEMFs or EA alone for improving maximum load (P<0. 05,P<0. 01) and energy to failure (P<0. 01) in L5 vertebral body. Conclusions Combination treatment with PEMFs and EA have additive ben-efits on BMD and bone biomechanical properties in the lumbar vertebral body.关键词
骨质疏松/骨密度/生物力学/脉冲电磁场/电针/联合治疗Key words
osteoporosis/bone mineral density/bone biomechanical properties/pulsed electromagnetic fields/electroacupuncture/combination treatment分类
医药卫生引用本文复制引用
周君,何红晨,肖登,陈世菊,刘慧芳,覃渝茜,何成奇..脉冲电磁场联合电针疗法对去卵巢大鼠骨质疏松的影响[J].中南医学科学杂志,2014,(4):331-335,342,6.基金项目
国家自然科学基金资助项目(81171865),湖南省卫生厅资助项目(B2014-052) （81171865）
