摘要
Abstract
Objective To observe the effect of pioglitazone on plasma leptin and insulin resistance in patients with impaired glucose tolerance(IGT)complicated by nonalcoholic fatty liver(NAFL). Methods Eighty patients with IGT complicated by NAFL displayed by B-ultrasound were enrolled and divided into control group ( treated with dietary and sports)and pioglitazone group(treated with pioglitazone,15mg once daily,for 12 weeks). Then the curative effects on two groups were compared in the aspects of blood glucose,blood lipid,liver functional tests,homeostasis assessment of insulin resistance(HOMA-IR),fasting blood insulin(Fins),plasma leptin,and liver B-ult-rasound values. Results Compared with the control group,the blood glucose,TC,TG,LDL,HOMA-IR,Fins,plasma leptin decreased and the B-ultrasound val-ues improved significantly(P<0. 05) in the patients of pioglitazone group. Conclusion Pioglitazone shows a better effi-cacy in reduction of the plasma leptin and insulin resistance in the patients with IGT complicated by NAFL.关键词
糖耐量异常/非酒精性脂肪肝/吡格列酮/瘦素Key words
IGT/nonalcoholic fatty liver/pioglitazone/leptin分类
医药卫生
