摘要
Abstract
Objective To compare the efficacy,safety,compliance difference of cefdinir and amoxicillin/clavulanate in treatment of children with acute otitis media(AOM). Methods 201 cases (232 ears) with AOM who received either cefdinir particles (daily dose of 7mg/kg/d,divided two times daily for 5 days) or amoxicillin/clavulanate(daily dose of 13. 3 mg/kg,divided two times daily for 10 days) treatment from 2011 January to 2012 December were reviewed retrospec-tively. According to the clinical symptoms and signs recovery,compare the efficacy,drug compliance and safety differences of two groups. Results At the end of treatment,104 ears were cured or improved (104/106,98. 11%) in the cefdinir group,while in the amoxicillin/clavulanate group 96 ears were cured or improved (96/106,90. 57%). Cefdinir was signifi-cantly better than amoxicillin/clavulanate in efficacy (P<0. 05). Totally 16 cases had poor medication adherence,1 case in the cefdinir group,other 15 cases in the amoxicillin/clavulanate group. The medication compliance of the Cefdinir group was 98. 9%(90/91),amoxicillin/clavulanate group was 86. 4%(95/110),there was significant difference between two groups (P<0. 05). Totally 6 cases appeared adverse reactions,including skin rash,diarrhea and nausea,2 cases in the cefdinir group,other 4 cases in the amoxicillin/clavulanate group. The rate of adverse reaction in the Cefdinir group was 2. 2%(2/91),the amoxicillin/clavulanate group 3. 6%(4/110),two groups had no significant difference (P>0. 05). Conclusion 5-day oral cefdidir treatment was significantly better than 10-day oral amoxicillin/clavulanate treatment for children acute o-titis media in efficacy、medication adherence and safety,it seems to be a better choice of short treatment.关键词
头孢地尼/阿莫西林克拉维酸钾/急性中耳炎/儿童Key words
cefdinir/amoxicillin/clavulanate/acute otitis media/children分类
医药卫生
