曲阜师范大学学报（自然科学版）Issue(2)：72-76,5.DOI:10.3969/j.issn.1001-5337.2014.2.005
8-甲氧基香豆素-3-甲酸甲酯的合成、晶体结构及抑菌活性
Synthesis,Crystal Structure and Anti-biological Activity of Methyl 8-Methoxycoumarin-3-carboxylate
摘要
Abstract
Under microwave irradiation,methyl 8-methoxycoumarin-3-carboxylate is synthesized by the con-densation reaction of 3-methoxy-2-hydroxybenzaldehyde and dimethyl malonate in methanol with good yield,and then the structur is characterized by elemental analysis,IR,1 HNMR and X-ray single crystal diffraction.The crys-tal belongs to monoclinic space group P21/c with a=0.40283(14)nm,b=2.4867(8)nm,c=1.0379(4)nm,β=93.272(4)°,Z=4,V=1.0380(6)nm3 ,R1=0.0560,wR2=0.1532.The compound is a planar molecule,and a three-dimension supramolecular structure is formed by the intermolecular C-H…O hydrogen bonds andπ-πstacking interactions.The inhibition of the compound on the growth of E.coli has been studied by the microcalori-metric method,and the result shows that the compound possesses good anti-bacterial activity.关键词
香豆素/8-甲氧基香豆素-3-甲酸甲酯/晶体结构/抑菌作用Key words
coumarin/methyl 8-methoxycoumarin-3-carboxylate/crystal structure/anti-bacterial activity分类
化学化工引用本文复制引用
安五改,王利芹,张振磊,辛月,杨淑梅,田来进..8-甲氧基香豆素-3-甲酸甲酯的合成、晶体结构及抑菌活性[J].曲阜师范大学学报（自然科学版）,2014,(2):72-76,5.基金项目
曲阜师范大学国家级大学生创新训练计划项目（201210446024）；山东省自然科学基金（ZR2013BM007）和国家自然科学基金（21302110）资助． （）
