器官移植Issue(4)：222-226,5.DOI:10.3969/j.issn.1674-7445.2014.04.006
肝移植治疗终末期自身免疫性肝病的预后分析
Prognostic analysis of liver transplantation in treating patients with end-stage autoimmune liver disease
摘要
Abstract
Objective To investigate the prognosis of patients underwent liver transplantation (LT) for end-stage autoimmune liver disease (AILD). Methods Clinical data of 48 patients with end-stage AILD undergoing LT from May 1996 to April 2013 in Affiliated Changzheng Hospital of the Second Military Medical University were analyzed retrospectively. The postoperative cumulative survival rates of the recipients were calculated,and the cause of death was analyzed. The postoperative rejections,new-onset viral hepatitis and AILD recurrence were analyzed. Results In 48 AILD recipients,38 cases survived and the postoperative 5-year cumulative survival rate was 76%. Causes of death for the 10 dead cases were multiple organ failure, liver graft failure,sepsis,pulmonary infection,hemorrhage,hepatic artery embolization and renal failure. In 48 AILD recipients,9 cases (19%) suffered acute rejection after operation,3 cases suffered new-onset hepatitis B infection in 1-2 years after operation,2 recipients suffered primary disease (primary biliary cirrhosis)recurrence 2 years after operation and all survived for a long term after positive treatments.Conclusions Most liver transplant recipients with end-stage AILD can obtain a long-term survival. Attentions should be paid on the immunosuppressive regimens in early period after LT,prevention of infection,rejection and postoperative new-onset viral hepatitis,timely diagnosis of primary disease recurrence.关键词
肝移植/自身免疫性肝病/自身免疫性肝炎/原发性胆汁性肝硬化/原发性硬化性胆管炎/肾上腺皮质激素Key words
Liver transplantation/Autoimmune liver disease/Autoimmune hepatitis/Primary biliary cirrhosis/Primary sclerosing cholangitis/Adrenocortical hormone分类
医药卫生引用本文复制引用
邹游,张磊,李瑞东,郭闻渊,丁国善,傅志仁,王正昕..肝移植治疗终末期自身免疫性肝病的预后分析[J].器官移植,2014,(4):222-226,5.基金项目
上海市科委国际合作项目 （）
